Global Antidepressant Drugs Market - 2023-2030

Global Antidepressant Drugs Market - 2023-2030

Global Antidepressant Drugs Market reached US$ 14.3 billion in 2022 and is expected to reach US$ 20.6 billion by 2030 growing with a CAGR of 8.7XX% during the forecast period 2023-2030.

Antidepressant drugs work by increasing levels of chemicals in the brain called neurotransmitters such as serotonin and noradrenaline that are linked to mood and emotion. Antidepressants are used to treat major depressive disorder, anxiety disorders, premenstrual dysphoric disorder (PMDD), and bipolar depression.

Antidepressants are often prescribed as the initial treatment for depression and can be used with other forms of therapy and exercise to manage symptoms. SSRIs (Selective serotonin reuptake inhibitors) are the most commonly prescribed class of antidepressants. An imbalance of serotonin can play a role in depression and these drugs fight depression symptoms by decreasing serotonin reuptake in the brain.

Furthermore, significant growth drivers such as increasing product approvals, awareness of depressive disorders, and research and developments give rise to future market growth. Significant key players like Eli Lilly and Company, GlaxoSmithKline Plc., LGM Pharma LLC, Apotex Inc., and others are actively operating in the market.

Dynamics

Increasing Research and Developments for Antidepressant Drugs

The global antidepressant drugs market has witnessed significant growth due to various recent research and developments. Depression is usually diagnosed on the basis of medical history and clinical and imaging findings. Also, advanced research and developments in treating major depressive disorder help to accelerate market growth.

For instance, in August 2023, Novartis AG declared that the drug Onfasprodil is under clinical development Phase II for Treatment Resistant Depression. Onfasprodil (MIJ-821) is used for the treatment of treatment-resistant depression, and major depressive disorder (MDD).

Additionally, in November 2022, Janssen Pharmaceutical declared the results from ESCAPE-TRD, a long-term, randomized, open-label phase 3b designed to evaluate the short- and long-term efficacy, safety and tolerability of flexibly dosed SPRAVATO compared with quetiapine extended-release (XR), both in combination with a continuing selective serotonin reuptake inhibitor (SSRI) in adults with treatment-resistant major depressive disorder (TRD).

The data shows that adults with treatment-resistant major depressive disorder (TRD) treated with SPRAVATO achieved significantly higher remission rates from Week 6 and response rates as early as day 15 in the study. Thus, due to the above factors, the market is expected to boost over the forecast period.

Increasing Approvals for Antidepressant Drugs

The global market for antidepressant drugs is anticipated to be driven by advancements in drug approval procedures which will streamline regulatory processes, stimulate innovation, improve patient access to therapies, and facilitate the availability of novel and efficient depression management choices globally.

For instance, in February 2023, the FDA approved the submission of a New Drug Application (NDA) for zuranolone for the treatment of major depressive disorder (MDD) and postpartum depression (PPD), according to a joint statement from Biogen Inc. and Sage Therapeutics, Inc. Adults with MDD and PPD are being treated with the investigational drug zuranolone once daily for 14 days.

In December 2021, Dr. Reddy’s Laboratories received U.S. Food and Drug Administration (USFDA) approval for Venlafaxine ER Tablets. It is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and Venlafaxine Extended Release tablets are indicated for major depressive disorder (MDD) and social anxiety disorder (SAD).

Side Effects Associated with Treatment Drugs will Hamper the Growth of the Market

Antidepressant medications work well to treat depression, but they can also have unpleasant side effects like nausea, weight gain, sexual dysfunction, and, in a small percentage of cases, a higher risk of suicidal thoughts. Antidepressant drug uptake may be constrained by the need for rigorous monitoring and evaluation of these safety issues, particularly in certain patient populations.

In addition, antidepressant medications have fewer well-known adverse effects. Among them are a decreased tolerance to alcohol, a raised risk of bleeding due to effects on platelet clotting, and potential interference with blood sodium levels, which could cause symptoms like headaches or confusion.

Segment Analysis

The global antidepressant drugs market is segmented based on drug class, depression disorder, distribution channel, and region.

Selective Serotonin Reuptake Inhibitors from the Drug Class Segment Accounted for Approximately XX% of the Global Antidepressant Drugs Market Share

Selective Serotonin Reuptake Inhibitor is expected to hold the largest market share over the period forecast owing to increasing clinical trials of SSRI treatment drugs. A total of 933 clinical trials were performed for the treatment of depression. For instance, according to clinicalTrials.gov, on July 13, 2023, the University of Minnesota conducted a clinical trial on the Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression. The purpose of this study is to evaluate the effectiveness of two adaptive treatment strategies (ATSs) for adolescent depression. The intervention involves selective serotonin reuptake inhibitor drugs like Fluoxetine, escitalopram, citalopram, fluvoxamine, or sertraline.

Additionally, on August 16, 2023, Janssen Research & Development, LLC conducted a clinical trial on the Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder. The purpose of this study is to assess the long-term safety and tolerability of aticaprant administered as adjunctive therapy to a current antidepressant (selective serotonin reuptake inhibitor) in all participants with major depressive disorder (MDD).

Geographical Penetration

North America Accounted for Approximately 38.4% of the Market Share in 2022

The global antidepressant drugs market is segmented into North America, Europe, Asia Pacific, South America, Middle East, and Africa. North America has maintained a significant proportion of the antidepressant drugs market in recent years, and this trend is anticipated to continue throughout the forecast period due to factors such as the rising FDA approvals, and research and developments in antidepressant drugs.

For instance, in August 2022, Axsome Therapeutics, Inc., a biopharmaceutical company specializing in novel therapeutics for central nervous system (CNS) disorders, got FDA approval for AUVELITY (dextromethorphan HBr - bupropion HCl) extended-release tablets. With this approval, AUVELITY becomes the first and only oral N-methyl D-aspartate (NMDA) receptor antagonist approved for the treatment of major depressive disorder (MDD) in adults.

Additionally, in December 2022, the FDA approved VRAYLAR (cariprazine) as an adjuvant therapy to antidepressants for the treatment of major depressive disorder (MDD) in adults, according to AbbVie. Cariprazine is marketed as VRAYLAR in the U.S., and it is FDA-approved to treat adults with depressive, acute manic, and mixed episodes associated with bipolar I disorder, as well as schizophrenia, in addition to being approved as an adjunctive therapy to antidepressants for treatment of MDD.

Competitive Landscape

The major global players in the market include Eli Lilly and Company, GlaxoSmithKline Plc., LGM Pharma LLC, Apotex Inc., Zhejiang Huahai Pharmaceutical Co. Ltd., AstraZeneca Plc., Takeda Pharmaceutical Co. Ltd, Pfizer Inc., Aurobindo Pharma Limited, and Merck KGaA among others.

COVID-19 Impact Analysis

The COVID-19 pandemic has had a significant impact on the global antidepressant drugs market. During the height of the pandemic, many healthcare systems were overwhelmed, and non-urgent medical procedures and screenings were postponed or canceled. This led to delays in antidepressant drug research and product launches. Clinical trials are vital for developing new treatments and improving outcomes in the antidepressant drugs market.

However, the pandemic disrupted the conduct of clinical trials, with many sites temporarily halting enrollment or modifying protocols to prioritize patient safety. This has led to delays in the completion of trials and the availability of new therapies. Moreover, the focus of research and development efforts shifted during the pandemic, with a significant emphasis on developing vaccines and treatments for COVID-19. Therefore, owing to the above factors, the antidepressant drugs market is expected to be moderately affected over the forecast period.

By Drug Class
• Monoamine Oxidase Inhibitors
Isocarboxazid
Phenelzine
Selegiline
Tranylcypromine
• Norepinephrine-Dopamine Reuptake Inhibitor
Amineptine
Bupropion
Desoxypipradrol
Dexmethylphenidate
Difemetorex
• Serotonin-Norepinephrine Reuptake Inhibitors
Desvenlafaxine
Duloxetine
Levomilnacipran
Milnacipran
Venlafaxine
• Selective Serotonin Reuptake Inhibitors
Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline
• Tricyclic Antidepressants
Amitriptyline
Amoxapine
Desipramine
Doxepin
Imipramine
Nortriptyline

By Depression Disorder
• Major Depressive Disorder
• Obsessive-Compulsive Disorder
• Generalized Anxiety Disorder
• Panic Disorder
• Others

By Distribution Channel
• Hospital Pharmacy
• Retail Pharmacy
• Online Pharmacy
• Others

By Region
• North America
U.S.
Canada
Mexico
• Europe
Germany
U.K.
France
Italy
Spain
Rest of Europe
• South America
Brazil
Argentina
Rest of South America
• Asia-Pacific
China
India
Japan
Australia
Rest of Asia-Pacific
• Middle East and Africa

Key Developments
• In March 2023, Alembic Pharmaceuticals received approval from the US Food & Drug Administration to market Brexpiprazole tablets in strengths of 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg. Brexpiprazole tablets are indicated as an adjunctive therapy to antidepressants for the treatment of major depressive disorder.
• In November 2022, Luye Pharma Group received marketing approval from China’s NMPA for the triple monoamine reuptake inhibitor Ruoxinlin (toludesvenlafaxine hydrochloride) to treat patients with major depressive disorder.

Why Purchase the Report?
• To visualize the global antidepressant drugs market segmentation based on drug class, depression disorder, distribution channel, and region, as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development.
• Excel data sheet with numerous data points of global antidepressant drugs market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.

The global antidepressant drugs market report would provide approximately 69 tables, 70 figures, and 195 Pages.

Target Audience 2023
• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies