Global 3D Cell Culture Market - 2022-2029

Global 3D Cell Culture Market - 2022-2029

Market Overview

The Global 3D cell culture market size was valued at US$ XX million in 2021 and is estimated to reach US$ XX million by 2029, growing at a CAGR of XX% during the forecast period (2022-2029).

A 3D cell culture is an artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. Unlike 2D environments, a 3D cell culture allows cells in vitro to grow in all directions, similar to how they would in vivo. These three-dimensional cultures are usually grown in bioreactors and small capsules.

Market Dynamics

The global 3D cell culture market growth is driven by the shifting preferences of the researchers toward the use of these cultures, especially in cancer research. The cells in these cultures grow three-dimensionally with zones of oxygen & nutrient gradients and cellular heterogeneity that closely reflects the in-vivo microenvironment.

The rising preference for 3D cell culture models as alternative tools for in vivo testing drives the market growth

The 3D cell culture market is witnessing stable growth due to factors, like the use of 3D cell culture models as alternative tools for in vivo testing, the development of automated large-scale cell culture systems, and the rising need for organ transplantation. The 3D cell culture and co-culture models have huge benefits since they not only enable drug safety and efficacy assessment in a more in vivo–like context than traditional 2D cell cultures, but they can eliminate the species differences that pose limitations in the interpretation of the preclinical outcomes, by allowing drug testing directly in human systems.

Additionally, with the increase in demand for organ transplantation, there is likely to be a demand for 3D cell cultures as there is a need to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. According to the organdonor.gov website of the United States Health Resources and Services Administration in October 2021, 107,103 patients were on the national organ transplant waiting list in the year 2020. Data from the website also states that each year, 39,000 organ transplants are conducted in the United States. Thus, the increase in organ transplants is increasing the demand for research models, where 3D cell cultures are used. Significant players have been focusing on product launches to cater to the specific requirements of the researchers. For instance, Thermo Fisher Scientific collaborated with Applikon Biotechnology and launched two new single-use bioreactor controller platforms-i-Control and EZ-Control.

A lack of experienced and skilled professionals will hamper the growth of the market

The disadvantages of cell culture are highly skilled personnel, techniques must be performed using strict asepsis techniques because animal cells grow slower than many of the common contaminants. But the biggest problem facing cell culture was contamination. Bacteria and a host of other microorganisms could find their way into cultures. These factors are hampering the growth of the market in the forecast period.

COVID-19 Impact Analysis

The COVID-19 pandemic is expected to have a significant impact on the market. Researchers working on COVID-19 with relevant matrices for 3D cell culture and suitable for air-liquid interface culture, need to investigate in vitro the mechanisms of the systemic consequences of cell cultures and to test potential therapies in a physiological microenvironment. This is the primary reason why 3D cell cultures are used in COVID-19 research. According to an article appearing in Frontiers Online in March 2021 titled, '3D Tissue Models as an Effective Tool for Studying Viruses and Vaccine Development', there are benefits of using 3D tissue culture techniques over 2D tissue culture when studying viral infections and the implications with regards to studying COVID-19. The study also found that techniques like organoids and spheroid cultures have been shown to replicate systems of viral infection more accurately than 2D cultures and to produce morphology and biochemical behaviors required to allow for viral infection in cases where 2D cultures do not.​

Segment Analysis

The microchips segment is expected to grow at the fastest CAGR during the forecast period (2022-2029)

Microchips are also called organ-on-a-chip or microsystems. Microchips can integrate microfluidic technologies with cells that are cultured within the microfabricated 3D devices, using various techniques from the microchip industry. For instance, according to the study published in the Analytical Method in June 2019, titled Integrating 3D cell culture of PC12 cells with microchip-based electrochemical detection research identified that microchip was able to separate and detect dopamine and norepinephrine release. Thus, microchip fabricated with 3D cell culture devices helps in the real-time analysis of neurotransmitter boost the segment over the forecast period.

2-dimensional (2D) culture models and animal models have been used for mechanism research and drug development. However, 2D models and animal models cannot mimic the physiology of human tissue, in terms of a number of cell types and properties. Thus, conventional models cannot precisely reflect humans and have not been able to accurately predict in vivo responses related to drug treatment. In this regard, many industries have been looking for and developing a new platform, to replace animal models or flask cell-culture models, and recently, organs-on-a-chip (OoCs) emerged as an alternative candidate for cell experiments and drug screening.

The main advantage of these chips is that they can be manufactured at a low cost. Furthermore, they allow for testing a wide range of concentrations in the dosage of medicine. This advantage is expected to drive the demand for microchips, primarily to considerably accelerate scientific research. In recent years, there have been innovative uses of organ chip technology for the drug discovery process. For instance, in March 2019, the private space exploration company SpaceX announced that it plans to soon launch a Dragon cargo capsule that will contain four microchips embedded with living human cells designed to model various aspects of human physiology. This is expected to speed up analysis and glean insights on human physiology that can be used later for drug development. These factors are driving the growth of the market in the forecast period.

Geographical Analysis

The North American region holds the largest market share of the global 3D cell culture market

The North American region is expected to dominate the 3D cell culture market. The United States is focusing on R&D and has been making significant investments in research on 3D cell culture, for the past few years. This has resulted in technological advancements in the country. Many American applicants feature among the main patent applicants for the 3D cell culture domain. American applicants tend to develop their technologies in the United States, as well as in Asia.

There have also been huge investments in the bioengineering sector in the United States over the past few years. Bioengineering involves 3D cell culture research too. According to the National Institute of Health, in 2020, the total investment in various bioengineering technologies amounted to USD 5,646, an increase from USD 5,091 in 2019. These factors have augmented the US 3D cell culture market.

Moreover, there is a need to mimic intricate elements of human physiology, pathology, and medication reactions in vitro, there is expected to be a demand for 3D cell cultures as the demand for organ transplantation grows in the region. According to the Canadian Institute for Health Information in 2021, a total of 3,014 transplant procedures (all organs) were performed in Canada (including Quebec), an increase of 42% since 2010. Thus, all the aforementioned factors are expected to drive the market in the region over the forecast period.

Competitive Landscape

The 3D cell culture market is a moderately competitive presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include BiomimX SRL, CN Bio Innovations, Corning Incorporated, Hurel Corporation, InSphero AG, Lonza AG, and Merck KgaA, MIMETAS BV, Nortis Inc., Thermo Fisher Scientific among others. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the 3D cell culture market globally. For instance, in August 2021, Amerigo Scientific expanded its cell culture portfolio with the launch of 3D Cell Culture for scientific uses. This new 3D cell culture system can use in research areas such as drug discovery, medicine, evaluation of nanomaterials, and basic life science.

Corning Incorporated

Overview:

Corning Incorporated is a global technology-based company. The Company produces optical fiber, cable, and photonic components for the telecommunications industry, as well as manufactures glass panels, funnels, liquid crystal display glass, and projection video lens assemblies for the information display industry.

Product Portfolio:

Corning Matrigel Matrix: Corning Matrigel matrix is effective for the attachment and differentiation of both normal and transformed anchorage-dependent epithelioid and other cell types. These include neurons, Sertoli cells, chick lens, vascular endothelial cells, and hepatocytes.

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Target Audience

Service Providers/ Buyers

Industry Investors/Investment Bankers

Education & Research Institutes

Research Professionals

Emerging Companies

Manufacturers

Market Segmentation

Global 3D Cell Culture Market – By Technique

Scaffold-Based

Scaffold-free

Microchips

3D Bioreactors

Global 3D Cell Culture Market - By Application

Cancer & Stem cell research

Tissue engineering & Immunohistochemistry

Drug development

Others

Global 3D Cell Culture Market – By End User

Biotechnology & Pharmaceutical Companies

Contract Research Laboratories

Academic Institutes

Global 3D Cell Culture Market - By Region

North America

Europe

Asia-Pacific

Middle East & Africa

South America