Protein A resin is a medium used for the purification of antibodies through affinity chromatography. Antibodies are the primary targets for affinity chromatography as they have specific regions of interaction with Protein A. Protein A is an Fc-binding bacterial protein isolated from Staphylococcus aureus. It selectively binds to the Fc region of antibodies of human and certain other species origin and allows for the effective purification of antibodies in a single step. Monoclonal antibodies form the backbone of biotherapeutics research currently. With increasing investments in developing novel therapeutics based on monoclonal antibodies, the demand for Protein A resins is consistently rising to enable large-scale downstream processing of these molecules.
Market Dynamics:
The global Protein A resin market is driven by the exponential growth of the biopharmaceutical industry and associated rise in the demand for monoclonal antibody therapeutics. The availability of technologically-advanced Protein A resins that allow efficient, high yield, and selective purification of antibodies is also propelling the market growth. However, high costs associated with Protein A media and lack of standardization in regeneration and sanitization protocols are hindering the market growth to an extent. The development of novel regenerated Protein A resins that enable multiple regeneration cycles without loss of binding capacity opens lucrative opportunities for manufacturers.
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