Plasmid DNA Manufacturing Market, By Product Type (Viral Vectors, Plasmid DNA and Non-viral Vectors), By Grade (GMP Grade, R&D Grade and Clinical Grade), By Application (DNA Vaccines, Gene Therapy, Immunotherapy, RNA Vaccines and Others), By Manufacturing Type (Outsourcing and In-house Manufacturing), By Development Phase (Pre-Clinical Therapeutics, Clinical Therapeutics and Marketed Therapeutics), By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis, 2022 - 2030
Circular double-stranded DNA present in the cytoplasm of a bacteria that replicate independently from the bacterial chromosome is called a plasmid DNA. Plasmids are small extra chromosomal DNA molecules within cells that are physically separated from the chromosomal DNA and capable of independent replication. They are most commonly found as small circular double-stranded DNA molecules in bacteria. However, plasmids can be present in archaea and eukaryotes.
Each plasmid has its own "origin of replication". This is a stretch of DNA that ensures it is replicated (copied) by the host bacteria. Because of this, plasmids can copy themselves independently of the bacterial chromosome, and there can be many, possibly hundreds, copies of the plasmid within the bacterial cell.
Market Dynamics
Demand for innovation in existing manufacturing technologies, in order to meet the requirement of appropriate products and its volume is expected to provide immense growth opportunities for key players in the market. For instance, in March 2021, Evolugate, LLC, a Gainesville-based biotech company, has demonstrated that its proprietary technology can be used to improve the throughput of plasmid DNA manufacturing.
The increasing inorganic strategies such as acquisition by the key players in the market to expand product portfolio is expected to drive the market growth over the forecast period. For instance, In January 2022, Aldevron announced the acquisition of Nature Technology Corporation (NTC), a developer of innovative and proprietary plasmid constructs and manufacturing solutions that are used in the field of cell and gene therapy. NTC's nucleic acid-based technologies include Nanoplasmid, a proprietary vector construct that improves the safety and performance of plasmids and biologics.
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