Nonalcoholic Steatohepatitis Treatment Market, by Drug (Cenicriviroc, Elafibranor, Ocaliva, and Selonsertib), by Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa)- Size, Share, Outlook, and Opportunity Analysis, 2022 - 2030
Non-alcoholic steatohepatitis (NASH) is the advanced form of non alcoholic fatty liver disease (NAFLD), a chronic disease marked by excessive fat accumulation in the liver. Nonalcoholic steatohepatitis (NASH) is a form of nonalcoholic fatty liver disease (NAFLD) in which a person have hepatitis and inflammation of the liver, which can cause liver damage. NASH can lead to complications, such as cirrhosis and liver cancer. Patients with NASH have high chance of mortality due to liver-related causes such as liver failure. Lifestyle modification, including change in diet and exercise, is the basic therapy recommended for nonalcoholic fatty liver disease. However, in some cases lifestyle modification is difficult to achieve and to sustain, and therefore requires other treatments including medicine. Currently available drugs for the treatment of NAFLD were historically being given for other indications. For instance, Orlistat, a gut lipase inhibitor, is indicated for decrease in the dietary fats absorption. According to the National Center for Biotechnology Information (NCBI) 2017 study, Orlistat has been approved for treatment of obesity and is available over the counter in the U.S. for weight loss. Orlistat-mediated weight loss is related with reduction in hepatic steatosis.
Market Dynamics
Obesity, high blood pressure and cholesterol level, type 2 diabetes and metabolic syndrome are the major causes of the nonalcoholic steatohepatitis onset. Increasing prevalence of these conditions worldwide is expected to drive the global nonalcoholic steatohepatitis treatment market growth during the forecast period. According to the International Diabetes Federation 2017 data, approximately 425 million people were suffering from diabetes in the world and 82 million cases were in the South East Asia region which is expected to reach 151 million by 2045. Moreover, in December 2021, according to the National Center for Biotechnology Information, in the U.S., the frequency of insulin resistance was observed to be 3% in the general population; a several-fold increase occurs in individuals with glucose intolerance. Worldwide, the prevalence of insulin resistance ranges from 15.5 to 46.5%, among adults. The total number of people with diabetes would rise from ∼11 million in 2000 to almost 20 million in 2025. By 2050, this is projected at >29 million people—a 165% increase over the 2000 level. It is to be noted that these projections imply a steady increase in the overall prevalence of diabetes, from 3.99% in 2000 to 7.21% in 2050.
However, diagnosis of the nonalcoholic steatohepatitis can be difficult to capture in an early stage and can take years before patients show any sort of symptoms which is a major factor hampering the nonalcoholic steatohepatitis treatment market.
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