Downstream Processing Market, By Technique (Purification Techniques, Solid-Liquid Separation, and Clarification/Concentration), By Product (Chromatography Columns and Resins, Filters, Evaporators, Centrifuges, and Other Products), By Application (Antibodi

Downstream Processing Market, By Technique (Purification Techniques, Solid-Liquid Separation, and Clarification/Concentration), By Product (Chromatography Columns and Resins, Filters, Evaporators, Centrifuges, and Other Products), By Application (Antibodies Production, Vaccines Production, Insulin Production, and Other Applications), By End User (Biopharmaceutical Companies, CMOs/CDMOs, Research Institutes, CROs, and Others), By Geography (North America, Latin America, Asia Pacific, Europe, Middle East, and Africa)


Downstream processing refers to the purification and recovery steps in bioprocessing undertaken after fermentation to isolate the active ingredient or product of interest from cellular biomass or fermentation broth. It involves clarification to remove cellular debris and components, concentration to separate and recover the target product by reducing volume, and final purification using chromatographic techniques. Downstream processing plays a critical role in ensuring the purity, quality, and stability of biopharmaceutical products, thereby determining their success in the market. Advances in technologies for clarification and purification such as expanded bed chromatographic separation and continuous processing have enabled higher product yields and throughput at reduced costs of goods.

Market Dynamics:

The downstream processing market growth is driven by the rapid growth of the biopharmaceutical industry, preference for biologics over small molecule drugs, and strong demand for monoclonal antibodies and vaccines. However, high costs associated with downstream purification equipment and operations acts as a restraint. Advancements in continuous manufacturing and single-use technologies provide significant opportunities for market players to develop innovative solutions for integrated and modular processes. Market leaders are focusing on partnerships and M&A activities to strengthen their portfolio of purification solutions and chromatography resins.

Key features of the study:
  • This report provides in-depth analysis of the global downstream processing market, and provides market size (USD Million) and compound annual growth rate (CAGR%) for the forecast period (2024–2031), considering 2023 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by key players
  • It profiles key players in the global downstream processing market based on the following parameters – company highlights, products portfolio, key highlights, financial performance, and strategies
  • Key companies covered as a part of this study include GE Healthcare, Merck KGaA, Thermo Fisher Scientific Inc., 3M Company, Lonza Group AG, Eppendorf AG
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
  • The global downstream processing market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global downstream processing market
Detailed Segmentation-
  • By Technique
  • Purification Techniques
  • Solid-Liquid Separation
  • Clarification/Concentration
  • By Product
  • Chromatography Columns and Resins
  • Filters
  • Evaporators
  • Centrifuges
  • Other Products
  • By Application
  • Antibodies Production
  • Vaccines Production
  • Insulin Production
  • Other Application
  • By End User
  • Biopharmaceutical Companies
  • CMOs/CDMOs
  • Research Institutes
  • CROs
  • Others
  • By Region:
  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East
  • Africa
  • Company Profiles:
  • Merck KGaA
  • Thermo Fisher Scientific Inc.
  • GE Healthcare
  • Sartorius Stedim Biotech S.A.
  • Repligen Corporation
  • Pall Corporation
  • M Company
  • Eppendorf AG
  • Agilent Technologies, Inc.
  • Waters Corporation
  • Shimadzu Corporation
  • Bio-Rad Laboratories, Inc.
  • Avantor Performance Materials, LLC
  • Tosoh Corporation
  • Column Technology Inc.
  • Purolite
  • R. Grace & Co.
  • Asahi Kasei Corporation
  • Novasep Holding S.A.S
  • Boehringer Ingelheim


1. Research Objectives and Assumptions
Research Objectives
Assumptions
Abbreviations
2. Market Purview
Report Description
Market Definition and Scope
Executive Summary
Market Snapshot, By Technique
Market Snapshot, By Product
Market Snapshot, By Application
Market Snapshot, By End User
Market Snapshot, By Region
Coherent Opportunity Map (COM)
3. Market Dynamics, Regulations, and Trends Analysis
Market Dynamics
Drivers
Restraints
Opportunities
Impact Analysis
Market Trends
Key Developments
Regulatory Scenario
Acquisitions and Partnerships Scenario
Funding and Investments
PEST Analysis
Porter’s Analysis
4. Global Downstream Processing Market - Impact of Coronavirus (COVID-19) Pandemic
Overall Impact
Government Initiatives
COVID-19 Impact on the Market
5. Global Downstream Processing Market, By Technique, 2019 – 2031, (USD Bn)
Overview
Market Share Analysis, 2024 and 2031 (%)
Y-o-Y Growth Analysis, 2020 – 2031
Segment Trends
Purification Techniques
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Solid-Liquid Separation
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Clarification/Concentration
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
6. Global Downstream Processing Market, By Product, 2019 – 2031, (USD Bn)
Overview
Market Share Analysis, 2024 and 2031 (%)
Y-o-Y Growth Analysis, 2020 – 2031
Segment Trends
Chromatography Columns and Resins
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Filters
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Evaporators
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Centrifuges
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Others
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
7. Global Downstream Processing Market, By Application, 2019 – 2031, (USD Bn)
Overview
Market Share Analysis, 2024 and 2031 (%)
Y-o-Y Growth Analysis, 2020 – 2031
Segment Trends
Antibodies Production
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Vaccines Production
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Insulin Production
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
Other Applications
Overview
Market Size and Forecast, and Y-o-Y Growth, 2019–2031, (USD Bn)
8. Global Downstream Processing Market, By Region, 2019 – 2031, (USD Bn)
Introduction
Market Share Analysis, By Region, 2024 and 2031 (%)
Y-o-Y Growth Analysis, For Region, 2020–2031
Regional Trends
North America
Introduction
Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 – 2031, (USD Bn)
U.S.
Canada
Latin America
Introduction
Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 – 2031, (USD Bn)
Brazil
Mexico
Argentina
Rest of Latin America
Europe
Introduction
Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 – 2031, (USD Bn)
U.K.
Germany
Italy
France
Spain
Russia
Rest of Europe
Asia Pacific
Introduction
Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 – 2031, (USD Bn)
China
India
Japan
ASEAN
Australia
South Korea
Rest of Asia Pacific
Middle East
Introduction
Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 – 2031, (USD Bn)
GCC
Israel
Rest of Middle East
Africa
Introduction
Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
Market Size and Forecast, and Y-o-Y Growth, By Country/Region, 2019 – 2031, (USD Bn)
North Africa
Central Africa
South Africa
9. Competitive Landscape
Company Profiles
Merck KGaA
Company Highlights
Product Portfolio
Key Highlights
Financial Performance
Market Strategies
Thermo Fisher Scientific Inc.
GE Healthcare
Sartorius Stedim Biotech S.A.
Repligen Corporation
Pall Corporation
M Company
Eppendorf AG
Agilent Technologies, Inc.
Waters Corporation
Shimadzu Corporation
Bio-Rad Laboratories, Inc.
Avantor Performance Materials, LLC
Tosoh Corporation
Column Technology Inc.
Purolite
W.R. Grace & Co.
Asahi Kasei Corporation
Novasep Holding S.A.S
Boehringer Ingelheim
10. Analyst Recommendations
Wheel of Fortune
Analyst View
Coherent Opportunity Map
11. References and Research Methodology
References
Research Methodology
About us and Sales Contact
*Browse 32 market data tables and 28 figures on Downstream Processing Market” - Global forecast to 2031

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