Global mRNA Raw Enzyme Market Research Report 2024(Status and Outlook)

Global mRNA Raw Enzyme Market Research Report 2024(Status and Outlook)

Report Overview

Already decades in development, the SARS-CoV-2 pandemic first thrust mRNA therapeutics into the limelight. From vaccines and immunotherapies to protein replacement and cell reprogramming, interest in mRNA manufacturing has surged. Today, therapeutic developers have the room and attention to bring innovations to market. Competition is growing. Regulations are crystalizing. Raw enzyme is one of the key raw materials for mRNA production.

mRNA Raw Enzyme are used in mRNA production on a global scale for vaccine and therapeutic development. The process includes DNA linearization, in vitro transcription, mRNA capping and tailing, purification, and analysis. mRNA Raw Enzyme including mRNA polymerase, vaccinia capping enzyme, restriction enzyme, DNASE I, others.

The global mRNA Raw Enzyme market was valued at USD 5761.81 million in 2021 and is expected to reach USD 2207.51 million by the end of 2028, growing at a CAGR of -16.02% between 2022 and 2028.

High demand for mRNA vaccine against coronavirus and coronavirus-modified diseases has become the most important driving force for the development of the mRNA Raw Enzyme market. The COVID-19 pandemic has favorably impacted the growth of the global mRNA Raw Enzyme market owing to an increase in the number of COVID-19 patients globally and substantial external financing for the production of mRNA-based COVID-19 vaccines. Furthermore, when new strains of the SARS-COVID-19 virus appeared in many countries around the world, the demand for mRNA vaccines rose sharply due to their effective protection against these strains.

Referring to the synthesis process of new crown mRNA vaccines such as Moderna and BioNTech, the main raw materials in the production process include plasmid DNA templates, a series of enzymes and substrate nucleotides. According to Frost & Sullivan, the cost of raw materials is the main component of the production cost of mRNA vaccines, accounting for about 58% of the total production cost, of which enzyme raw materials account for about 39.58% of the cost of raw materials. In addition to substrate nucleotides, the preparation of mRNA stock solution currently requires T7 RNA polymerase, inorganic pyrophosphatase, RNase inhibitor, capping enzyme, 2'O-methyltransferase, Poly(A) polymerase and DNase I and other major 7 enzymes.

Considering that the current global new crown epidemic is still in a high incidence period and the risk of virus mutation is high, vaccination is an important measure to control the epidemic, and after vaccination, it has significantly reduced the severe rate and mortality rate. Therefore, we expect global new crown mRNA vaccination volume is expected to remain high in the next three years. Hence, the use of these mRNA-based products is expected to increase during the COVID-19 pandemic and lead to mRNA Raw Enzyme market growth.

However, the duration of the new crown epidemic is uncertain. With the gradual and effective control of the new crown epidemic or the successful development of specific drugs for the treatment of new coronary pneumonia, related companies' new crown diagnostic antibodies, mRNA raw materials enzymes and reagents and other new crown business income will drop significantly.

High demand for mRNA vaccine against coronavirus and coronavirus-modified diseases has become the most important driving force for the development of the mRNA Raw Enzyme market.

Segment by Type, the mRNA Raw Enzyme can be split into mRNA Polymerase, Vaccinia Capping Enzyme, Restriction Enzyme and DNase I. In 2017-2021, mRNA Polymerase and Vaccinia Capping Enzyme are the most important markets for the mRNA Raw Enzyme, occupying the most important market share. In 2021, the market share of the mRNA Polymerase segment has reached 46.34%, and the market share of the Vaccinia Capping Enzyme segment has reached 39.52%.

From the perspective of application scenarios, the mRNA Raw Enzyme can be mainly used in Biopharmaceutical Companies, Academic and Research Institutes and Contract Research Organizations. Among them, Biopharmaceutical Companies has become the most important application scenario of mRNA Raw Enzyme, and has accounted for 97.93% in 2021 market share. Biopharmaceutical Companies use mRNA Raw Enzyme to make mRNA vaccines and related products.

On basis of geography, the mRNA Raw Enzyme market is segmented into North America, Europe, Japan, China, etc. North America and Europe are the most dominant markets, accounting for 48.12% and 48.70% market share respectively in 2021. Availability of substantial research funding, high frequency of RNA-based drugs and clinical trials drive the European and North American markets.

In terms of the competitive landscape, the raw material suppliers of major mRNA vaccine manufacturers in the world are mainly Thermo Fisher (whose products cover transcription modification enzymes, cap analogs and NTP raw materials, etc., with a complete product line), NEB (with a complete transcription capping enzyme system) and NTP) and other companies. Among them, Thermo Fisher is the absolute leading company in the mRNA Raw Enzyme market, and occupies 66.66% of the market share. Overall, key players in the market include Thermo Fisher, Roche Holding AG, New England Biolabs, Novoprotein, Hongene Biotech Corporation, Vazyme, Kactus Biosystems, Aldevron and Yeasen Biotechnology (Shanghai).

This report provides a deep insight into the global mRNA Raw Enzyme market covering all its essential aspects. This ranges from a macro overview of the market to micro details of the market size, competitive landscape, development trend, niche market, key market drivers and challenges, SWOT analysis, value chain analysis, etc.

The analysis helps the reader to shape the competition within the industries and strategies for the competitive environment to enhance the potential profit. Furthermore, it provides a simple framework for evaluating and accessing the position of the business organization. The report structure also focuses on the competitive landscape of the Global mRNA Raw Enzyme Market, this report introduces in detail the market share, market performance, product situation, operation situation, etc. of the main players, which helps the readers in the industry to identify the main competitors and deeply understand the competition pattern of the market.

In a word, this report is a must-read for industry players, investors, researchers, consultants, business strategists, and all those who have any kind of stake or are planning to foray into the mRNA Raw Enzyme market in any manner.

Global mRNA Raw Enzyme Market: Market Segmentation Analysis

The research report includes specific segments by region (country), manufacturers, Type, and Application. Market segmentation creates subsets of a market based on product type, end-user or application, Geographic, and other factors. By understanding the market segments, the decision-maker can leverage this targeting in the product, sales, and marketing strategies. Market segments can power your product development cycles by informing how you create product offerings for different segments.

Key Company

Thermo Fisher

Roche Holding AG

New England Biolabs

Novoprotein

Hongene Biotech Corporatio

Vazyme

Kactus Biosystems

Aldevron

Yeasen Biotechnology (Shanghai)

Market Segmentation (by Type)

mRNA Polymerase

Vaccinia Capping Enzyme

Restriction Enzyme

DNase I

Others

Market Segmentation (by Application)

Biopharmaceutical Companies

Academic and Research Institutes

Contract Research Organizations

Geographic Segmentation

North America (USA, Canada, Mexico)

Europe (Germany, UK, France, Russia, Italy, Rest of Europe)

Asia-Pacific (China, Japan, South Korea, India, Southeast Asia, Rest of Asia-Pacific)

South America (Brazil, Argentina, Columbia, Rest of South America)

The Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, South Africa, Rest of MEA)

Key Benefits of This Market Research:

Industry drivers, restraints, and opportunities covered in the study

Neutral perspective on the market performance

Recent industry trends and developments

Competitive landscape & strategies of key players

Potential & niche segments and regions exhibiting promising growth covered

Historical, current, and projected market size, in terms of value

In-depth analysis of the mRNA Raw Enzyme Market

Overview of the regional outlook of the mRNA Raw Enzyme Market:

Key Reasons to Buy this Report:

Access to date statistics compiled by our researchers. These provide you with historical and forecast data, which is analyzed to tell you why your market is set to change

This enables you to anticipate market changes to remain ahead of your competitors

You will be able to copy data from the Excel spreadsheet straight into your marketing plans, business presentations, or other strategic documents

The concise analysis, clear graph, and table format will enable you to pinpoint the information you require quickly

Provision of market value (USD Billion) data for each segment and sub-segment

Indicates the region and segment that is expected to witness the fastest growth as well as to dominate the market

Analysis by geography highlighting the consumption of the product/service in the region as well as indicating the factors that are affecting the market within each region

Competitive landscape which incorporates the market ranking of the major players, along with new service/product launches, partnerships, business expansions, and acquisitions in the past five years of companies profiled

Extensive company profiles comprising of company overview, company insights, product benchmarking, and SWOT analysis for the major market players

The current as well as the future market outlook of the industry concerning recent developments which involve growth opportunities and drivers as well as challenges and restraints of both emerging as well as developed regions

Includes in-depth analysis of the market from various perspectives through Porter’s five forces analysis

Provides insight into the market through Value Chain

Market dynamics scenario, along with growth opportunities of the market in the years to come

6-month post-sales analyst support

Chapter Outline

Chapter 1 mainly introduces the statistical scope of the report, market division standards, and market research methods.

Chapter 2 is an executive summary of different market segments (by region, product type, application, etc), including the market size of each market segment, future development potential, and so on. It offers a high-level view of the current state of the mRNA Raw Enzyme Market and its likely evolution in the short to mid-term, and long term.

Chapter 3 makes a detailed analysis of the market's competitive landscape of the market and provides the market share, capacity, output, price, latest development plan, merger, and acquisition information of the main manufacturers in the market.

Chapter 4 is the analysis of the whole market industrial chain, including the upstream and downstream of the industry, as well as Porter's five forces analysis.

Chapter 5 introduces the latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.

Chapter 6 provides the analysis of various market segments according to product types, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.

Chapter 7 provides the analysis of various market segments according to application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.

Chapter 8 provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space, and capacity of each country in the world.

Chapter 9 introduces the basic situation of the main companies in the market in detail, including product sales revenue, sales volume, price, gross profit margin, market share, product introduction, recent development, etc.

Chapter 10 provides a quantitative analysis of the market size and development potential of each region in the next five years.

Chapter 11 provides a quantitative analysis of the market size and development potential of each market segment (product type and application) in the next five years.

Chapter 12 is the main points and conclusions of the report.