3D Cell Cultures: Technologies and Global Markets
Report Scope: This report aims to provide a comprehensive study of the global 3D cell culture technologies market. It provides a detailed description of the different types of healthcare interoperability solutions and their current and historical market revenues. The scope of the report encompasses the major types of 3D cell culture which are being used by industry, academic researchers, government labs, and independent research groups. This includes the main inputs such as cell lines, media, sera, reagents, software, and instrumentation. It analyzes the current market status, examines future market drivers and presents forecasts of growth over the next five years. The market structure has been reorganized for this edition. Also, more research was done on base case data for different product areas. The greater emphasis is on the different products used for 3D cell culture, but the report also investigates the market in terms of types of applications, end users and geographic regions. Report Includes: - 17 data tables and 105 additional tables - An overview of the global market landscape related to the 3D cell cultures technologies - In-depth analysis of global market trends, featuring historical revenue data for 2020-2022, estimated figures for 2023, as well as forecasts for 2028. This analysis includes projections of Compound Annual Growth Rates (CAGRs) spanning through 2028 - Evaluation of the current market size and revenue growth prospects specific to 3D cell cultures technologies, accompanied by a comprehensive market share analysis categorized by type, end user, and geographical region - Information on analytical systems used in tissue and cell culture, cellomics, and human cancer model initiative (HCMI) - Details about assay development for mesenchymal stem cells, In Vitro testing of adventitious agents and description of assays and assay kits - A look at the main classes of models for researching cancer and other diseases, benefits of 3D models to cancer research and description of 3D engineered scaffolds - Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities and discussion on the impact of COVID-19 on the world of cell culture - Insights into U.S. regulatory status of bioprinted products; basic guidance for the regulation of biologics, regenerative medicine and xenotransplants - Relevant patent analysis, including recent activity and a list of key patents - Detailed profiles of leading market participants, providing a descriptive overview of their respective businesses, including Abcam PLC, Agilent Technologies Inc., Corning Inc., Merck KGAA, Beckman Coulter, and Synvivo Inc.
Table of Contents Chapter 1 Introduction Study Goals and Objectives Reasons for Doing the Study Scope of Report What's New in This Report? Methodology and Information Sources Geographic Breakdown Segment Breakdown Chapter 2 Summary and Highlights Market Outlook Market Summary Chapter 3 Market Overview An Opening Comment on an Amazing Industry Industry Issues In Vitro versus In Vivo Dimensionality The Research Chain for 2D and 3D Cell Culture Best Practices Standardization Regulation Genomics Forcing the Hand of the FDA Leachables and Extractables Broad Issues Research Talent Shortages The Shifting International Picture Pace and Diversification of Innovation A Comment on the "Other" Areas of Cell Culture Omics Everywhere Is 2020 a Watershed Year for the Cell Culture Industry? Preliminary Market Analysis Cell Culture Market Growth Rate Estimates Assessing Large-Scale Media Consumption Needs Modeling Future Growth in Biopharmaceuticals Base Case for the Cell Culture Market Challenges in Projecting Sales and Growth Cell Culture Media Market Estimates Cell and Gene Therapy Bioprocessing Segment Evaluating Media Consumption for Biosimilars What About CDMOs? Microfluidics Bioreactors Internal Cell Culture Resources Is There Too Much Concentration of Ownership in Biotechnology? Characterizing Innovation in 3D Cell Culture Bioprinting Strategic Roadmap Chapter 4 Market, by Type Where Did Tissue and Cell Culture Start? History and Early Applications Invention of Tissue Culture Development of Sustained Cell Lines First Cell Culture Flask and Rigorous Techniques Lindbergh: The Cell Culture Equipment Pioneer Establishing Continuous Cell Lines Key Developments in Equipment Terminology and Concepts Tissue and Cell Culture Industry Tissue Culture and Cell Culture Definitions Cell Lines Care and Growth of Cell Culture Systems Media, Sera, and Reagents Gels and Scaffolds Microplates/Microtiter Plates Bioanalytical Instruments Bioanalytical Imaging Bioprinting Bioreactors Other Equipment for Cell Culture Adherent Approaches Traditional Roller Bottles Other Systems Information Technology: Software and Services for the Cell Culture Research Market Software for the Research Market in Cell Culture Software-Related Support Services Bioprocessing Consumables for Cell Culture Microcarriers for Large-Scale 3D Culture Sera for Large-Scale 3D Culture Media for Large-Scale 3D Culture Bioreactor Bags for Large-Scale 3D Culture Other Bioprocessing Equipment Analytical Equipment for Bioprocessing Automation Systems for Bioprocessing Support Equipment for Bioprocessing Aspects of Large-Scale Manufacturing of Biopharmaceuticals and Vaccines Suspension Proteins and Monoclonal Antibodies Adherent-Cell-Based Therapies and Vaccines Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues Vaccines Vaccine Development as a Catalyst Vaccines Developed Using Human Cell Strains Exosome Manufacturing Viral Vector Manufacturing Lentivirus Manufacturing Plasmid Manufacturing Cell Culture End Users Pharma/Biopharma Universities Government CROs/CDMOS Other Cell Culture Applications Drug Discovery Clinical Development Toxicology Basic Research Bioprocessing Development Other Regional Markets The Americas Europe Asia-Pacific Rest of the World Chapter 5 Assays, Imaging and Analysis Assays Assay Development for Mesenchymal Stem Cells In Vitro Testing of Adventitious Agents Assays and Assay Kits Cell-Based Assays: Overview and Newer Developments Cells Used in Cell-Based Assays Notes on 3D Cell-Based Assays Kinetic Metabolism Assays Cell Proliferation Viability and Cytotoxicity Permeability Assays for Cell Viability and Survival Cell Invasion Cell Signaling and Communication Cytostatic Cell Death Assays Imaging Technology Imaging Assays Fluorescence as a Driver of Screening Analytical Systems Used in Tissue and Cell Culture Understanding "Cellomics" HCS Support of 3D Cell Culture NGS Discovery Pools Multiplex Assays Predictive Toxicology Neuro Safety The Omics Invasion Transcriptomics Chapter 6 Regulation and Standardization U.S. Regulatory Status of Bioprinted Products Basic Guidance for the Regulation of Biologics Guidance for Regenerative Medicine Guidance for Xenotransplants Guidance for Regenerative Medicine: Emergency Approval Regulating Bioprinted Products Chapter 7 3D Models for Cancer Disease Modeling Cancer Main Classes of Models for Researching Cancer and Other Diseases Cell Lines Spheroids and Organoids Genetically Engineered Mouse Model (GEMM) Patient-Derived Tumor Xenografts (PDXs) Overview: Cancer at the Cellular Level In Vivo (Animal) Testing Standard Empire of the Mouse Humanized Mice 2D Culture 3D Requirements Cell Number and Viability Migration and Invasion Unmet Needs: Angiogenesis and Immune System Evasion Benefits of 3D Models to Cancer Research Greater Distinction in Cell Morphology and Proliferation Greater Gene Expression and Cell Behavior Better Models of Cell Migration and Invasion Cell Heterogeneity Breast Cancer as a Driver of 3D Cultures Structure, Polarity and Apoptosis Melanoma as a Driver of 3D Cultures Moving to Spheroid Configurations 3D Systems in Cancer Research Multicellular Tumor Spheroids Multilayered Cell Cultures 3D Engineered Scaffolds Natural Materials Synthetic Materials Human Cancer Model Initiative (HCMI) Next-Generation Human Cancer Models Drug Sensitivity and Resistance Altered Signaling and Sensitivity Drug Resistance Cellular Signaling Cellular Signaling Mediated by Integrins Drug Screening Approaches and Endpoints Spheroid Applications Metastasis via 3D Cell Migration Model Metastasis via Lung-on-Chip Cancer Metabolism Future Horizons Metastases Co-culture Vascularization Cancer-Associated Fibroblasts Cancer Stem Cells Combination Therapies Biologics Development Tumor Recurrence Patient-Derived Cells Patient-Derived Tumor Xenografts (PDXs) Evolution of PDX Platforms Chapter 8 Landscape for Toxicology and Drug Safety Testing Introduction Liver Toxicology Background Testing for Adverse Effects on the Skin New Assessment Methodologies Impact on 3D Cell Culture Toxicology Testing in Cosmetics Updated Regulatory Requirements Efficacy of Cosmetics and Cosmeceuticals Aspects of Cosmetic Toxicity Testing Skin Irritation Skin Corrosion Phototoxicity Skin Sensitization Eye Irritation Acute Systemic Toxicity Acute Toxicity Testing Cytotoxicity Assays for Acute Toxicity Testing Chronic and Repeated Dose Toxicity Carcinogenicity and Genotoxicity Overview In Vitro Methods: Background and Recent Developments Regulatory versus Drug Development Applications Efforts to Reduce False Positives Recent Innovations in Screening Future Challenge: Non-genotoxic Carcinogens Reproductive and Developmental Toxicity Background Following the Reproductive Cycle Development and Reproductive Tox Testing Types Zebrafish Model for Developmental Toxicity Screening Combination of Zebrafish and Stem Cells Biomedical Frontiers: Male Testis Endocrine Disruptor Screening Background Environmental Toxicology Impacts In Vitro Methods ToxCast and Tox 21 Initiatives Future Challenge: Thyroid Disruption BG1 Assay Toxicokinetics and ADME In Vitro Developments Metabolism Pharmacokinetics of Low-Turnover Compounds Organotypic Models 3D Models for Skin 3D Corneal System Absorption Barrier Models Gastrointestinal Lung Blood-Brain Barrier Real Architecture for 3D Tissue Barriers and Extracellular Matrix Liver Toxicity Uniqueness and Complexity of Liver Liver as a Key Driver for 3D Innovation In Vitro Liver Applications In Vivo Liver Function and Structure Liver Metabolism In Vitro Liver Models Co-cultures of Hepatocytes and Macrophages 3D Liver Models Bioprinted Liver Tissue Detected Hepatosphere Structures and Functionality Ideal Criteria Drug Resistance Transporter Studies Achieving Heterotypic Cell-Cell Contacts Unmet Needs and Future Drivers of Innovation Morphogen Signaling Multi-donor Liver Cells Kidney Toxicity Applications Future Challenge: Stem-Cell Derived Kidney Cells Bioprinted Kidney Tissue Pancreatic Toxicology Applications Cardiovascular Toxicity Commercial Avenue Collaboration with Regulators Cardiovascular Drug Discovery Microelectrode Arrays (MEAs) Based on Impedance Surrogate for Aortic Ring Assay via Bioprinted Magnetics Vasodilator Activity 3D Engineered Heart Tissues Chapter 9 Market Breakdown by Region Introduction North America United States Canada Europe Germany United Kingdom Asia-Pacific China Japan India South Korea Singapore Rest of the World Chapter 10 Stem Cell Landscape A History of Stem Cells Major and Minor Research Areas for Stem Cells 3D Stem Cell Culture Systems Plate or Culture Dish Spinner Flask and Rotating Wall Vessel Perfusion Bioreactor and Microcarrier Systems Shortcomings Microfluidics and Stem Cells Short Review of Stem Cell Biology Embryogenesis Growth, Structure and Morphology of Stem Cells Stem Cell Differentiation Stem Cell Differentiation versus Proliferation Extracellular Matrix and Stem Cells Soluble Factors Manufacturing Stem Cells Controlling Embryoid Body Formation Forced Aggregation Cultures Hanging-Drop Approach Applications Stem Cell Markers for High-Throughput Screening Teratomas and the Teratoma Assay Fujifilm (Cellular Dynamics Inc.) Stem Cell Research Breakthroughs Stem Cells for Neuroscience Discovery and Development Example: Alzheimer's Research Background: B-Amyloid Cascade Hypothesis Human iPSC-Derived Models New 3D Model Other Advantages of 3D Envisioned Applications Other 3D Neuro Applications Stem Cells for Cardiovascular Discovery Stem Cells for the Development of Regenerative Medicine Background: Allogenic versus Autologous MicroRNAs Induced Pluripotent Stem Cells (IPS) Chapter 11 Regenerative Medicine: Organ Transplants and Skin Substitutes Regenerative Medicine Need for Organ Transplants Applications in Regenerative Medicine Investments in Regenerative Medicine Skin Substitutes Industry Tissue Culture Allograft and Autograft Products Tissue Engineering in Regenerative Medicine Chapter 12 Company Profiles 3D BIOPRINTING SOLUTIONS 3D BIOTEK LLC 4D TECHNOLOGY CORP. ABCAM PLC AKRON BIOTECH AGILENT TECHNOLOGIES INC. ALPCO AMSBIO BECKMAN COULTER INC. BIOINSPIRED SOLUTIONS BIOTIME INC. BIOVISION INC. CELL APPLICATIONS INC. CELLINK CORNING INC. CYPROTEX CYTIVA CYTOO SA EMD MILLIPORE / MERCK KGAA EMULATE INC. ENVISIONTEC INC. EPITHELIX EUROFINS SAS GREINER BIO-ONE INTERNATIONAL GMBH HAMILTON ROBOTICS HUB ORGANOIDS HUREL CORP. INSPHERO INVITROCUE KIYATEC INC. LIFENET HEALTH LOREM VASCULAR / CYTORI THERAPEUTICS INC. MATTEK MIMETAS INC. ORGANOVO HOLDINGS INC. PERKINELMER INC. PLASTICELL LTD. PLURISTEM THERAPEUTICS INC. POIETIS PROMEGA CORP. SEAHORSE BIOSCIENCE STEMCELL TECHNOLOGIES STRATATECH CORP. SYNVIVO INC. TAP BIOSYSTEMS TECAN TRADING AG ZEN-BIO INC.
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