Incretin-Based Drugs Market By Drug Class (GLP-1 receptor agonists, DPP-4 inhibitors), By Route of Administration (Parenteral, Oral), By Distribution Channel (Hospital Pharmacies, Drug Stores and Retail Pharmacies, Online Providers): Global Opportunity Analysis and Industry Forecast, 2023-2032
The global incretin-based drugs market was valued at $34.3 billion in 2022, and is projected to reach $73.9 billion by 2032, registering a CAGR of 7.9% from 2023 to 2032. Incretins are a group of gastrointestinal polypeptides that control insulin production in pancreatic beta cells. Incretins are essential for the regulation of insulin production and the metabolism of glucose in the body, especially after food intake. Glucagon-like peptide-1 or GLP-1 is a hormone secreted by the digestive tract in response to food. It stimulates insulin secretion from the pancreatic beta cells and helps to lower blood glucose levels after meals. These incretins release insulin not only when blood glucose levels rise but also when glucose levels are expected to rise, helping to regulate glucose levels. However, these incretin hormones are rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4), which decreases their effectiveness and duration of action in the body.
To enhance the action of incretins in managing type 2 diabetes, pharmaceutical approaches include the use of DPP-4 inhibitors and GLP-1 analogues. The DPP-4 inhibitors work by blocking DPP-4 activity. These drugs increase the levels of circulating glucagon-like peptides (GLP-1) and gastric inhibitory peptide (GIP). These hormones have a longer-lasting effect on insulin secretion and glucose regulation. On the other hand, synthetic GLP-1 drugs are GLP-1 transporters that are more tolerant to DPP-4 degradation. They work by mimicking the action of natural GLP-1. These drugs increase insulin release, inhibit glucagon secretion, slow gastric emptying, and reduce appetite.
The growth of incretin-based drugs market is mainly attributed to the high prevalence of type 2 diabetes population around the globe. Type 2 diabetes is a condition in which blood sugar levels are too high and the body is not able to produce enough insulin. The number of people with type 2 diabetes is on the rise, due to the rise in obesity around the world. Diabetes mellitus (Type 2) is currently treated using incretin-based drugs. These drugs control glucose metabolism in a variety of ways, are associated with low levels of hypoglycemia, and either do not affect body weight or do not stimulate weight loss. Thus have a huge demand in the treatment of this condition, which propels the growth of the incretin-based drugs market.
In addition, incretin-based drugs have shown promising results in weight loss or weight neutrality. This makes them attractive to a wider patient base interested in obesity management. Furthermore, ongoing R&D efforts to enhance the effectiveness, safety, and delivery mechanisms of the incretin-based therapies have also contributed to market expansion. The growing knowledge of the biology behind incretin and its impact on various metabolic disorders continue to drive innovation. This is anticipated to drive the market for incretin-based drugs in coming years.
However, the high cost of the treatment and regulatory challenges may hamper market growth to some extent. Incretin based drugs are usually more expensive than traditional diabetes drugs. Cost becomes a major issue, especially in areas where healthcare costs are high, which may limit access to these drugs. Also, the market is affected by stringent regulations and approval procedures by regulatory bodies such as the Food and Drug Administration (FDA) in the U.S. and the European Medicines Agency (EMA) in Europe. Delays or complexity in the approval of new drugs or indications may impede market growth. The incretin-based drugs market is segmented on the basis of drug class, route of administration, distribution channel, and region. On the basis of drug class, the market is divided into GLP-1 receptor agonists and DPP-4 inhibitors. On the basis of route of administration, the market is classified into oral and parenteral. By distribution channel, the market is categorized into hospital pharmacies, drug stores & retail pharmacies, and online providers. By region, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.
Major players profiled in this report are Eli Lilly and Company., Merck & Co., Inc., GlaxoSmithKline plc, Sanofi, Sun Pharmaceutical Industries Ltd., Lupin, Boehringer Ingelheim International GmbH, Novo Nordisk A/S, AstraZeneca plc and Takeda Pharmaceutical Company Ltd.
Key Benefits For StakeholdersThis report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the incretin-based drugs market analysis from 2022 to 2032 to identify the prevailing incretin-based drugs market opportunities.
The market research is offered along with information related to key drivers, restraints, and opportunities.
Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
In-depth analysis of the incretin-based drugs market segmentation assists to determine the prevailing market opportunities.
Major countries in each region are mapped according to their revenue contribution to the global market.
Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
The report includes the analysis of the regional as well as global incretin-based drugs market trends, key players, market segments, application areas, and market growth strategies.
Key Market SegmentsBy Drug ClassGLP-1 receptor agonists
DPP-4 inhibitors
By Route of AdministrationOral
Parenteral
By Distribution ChannelHospital Pharmacies
Drug Stores and Retail Pharmacies
Online Providers
By RegionNorth America
U.S.
Canada
Mexico
Europe
Germany
France
UK
Italy
Spain
Rest of Europe
Asia-Pacific
Japan
China
India
Australia
South Korea
Rest of Asia-Pacific
LAMEA
Brazil
Saudi Arabia
South Africa
Rest of LAMEA
Key Market PlayersEli Lilly and Company.
Takeda Pharmaceutical Company Ltd.
Lupin
Novartis AG
Merck & Co., Inc.
Sun Pharmaceutical Industries Ltd.
Boehringer Ingelheim International GmbH
Sanofi
Novo Nordisk A/S
AstraZeneca plc
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