Hydrophobic Interaction Chromatography Market By Product and Service (Product, Service), By Sample type (Monoclonal antibodies, Vaccines, Cell culture sample, Plasma and serum sample, Others), By Application (Protein and antibody purification, Vaccine dev

Hydrophobic Interaction Chromatography Market By Product and Service (Product, Service), By Sample type (Monoclonal antibodies, Vaccines, Cell culture sample, Plasma and serum sample, Others), By Application (Protein and antibody purification, Vaccine development, Drug discovery, Food and dietary supplement development), By End user (Pharmaceutical and biopharmaceutical companies, Contract research organizations and contract manufacturing organizations, Research and academic institutes, Others): Global Opportunity Analysis and Industry Forecast, 2024-2033

The hydrophobic interaction chromatography market was valued at $461.89 million in 2023 and is estimated to reach $952.93 million by 2033, exhibiting a CAGR of 7.5% from 2024 to 2033.

Hydrophobic interaction chromatography (HIC) is a chromatographic technique that separates proteins and other biomolecules on the basis of their hydrophobicity. It utilizes a solid support, typically a column packed with hydrophobic groups, which interacts with the hydrophobic regions of proteins under high salt conditions. In this technique, proteins bind at high salt concentration and remove at low salt concentration. HIC is widely applied in protein purification, antibody isolation, and separation of hydrophobic compounds in biotechnological and pharmaceutical industries. Its mechanism relies on the reversible binding of proteins to hydrophobic groups on the stationary phase, influenced by the ionic strength of the mobile phase.

The hydrophobic interaction chromatography market growth is driven by surge in demand for biopharmaceutical products, advancements in protein purification technologies, and increase in focus on high-quality therapeutics. The biopharmaceutical industry has witnessed significant growth in recent years, with the need for efficient and scalable protein purification methods becoming more critical. HIC, due to its ability to separate proteins on the basis of their hydrophobicity, is widely used in the purification of monoclonal antibodies, enzymes, and vaccines, contributing to its market expansion.

Furthermore, the increase in need for targeted and personalized medicine boosts the demand for advanced purification techniques such as HIC. As more biologic drugs are developed, the need to ensure their purity, quality, and safety is paramount. HIC is essential in this regard, particularly in separating proteins with high precision, which is crucial for regulatory approvals and maintaining product standards. The growing biopharmaceutical pipeline, especially in oncology, immunotherapy, and gene therapies, is pushing the adoption of HIC techniques to ensure the production of high-purity biologic drugs. Moreover, stricter guidelines regarding the safety, efficacy, and purity of biopharmaceuticals further highlight the need for effective purification methods such as HIC. These factors, coupled with surge in use of bioprocessing and biomanufacturing technologies, are expected to drive the hydrophobic interaction chromatography market expansion in the coming years.

Furthermore, rise in technological innovations, such as improvements in chromatography resins, automation, and high-performance systems, have made HIC more cost-effective and scalable, enhancing its appeal for large-scale manufacturing, thereby boosting market growth. Stringent regulatory requirements for biologic drug production, particularly those enforced by agencies such as the FDA and EMA, promote the adoption of HIC for high-purity production, as it ensures compliance with quality control standards. Furthermore, the rise in trend of contract manufacturing organizations (CMOs) outsourcing biomanufacturing services has accelerated the need for efficient and reliable purification methods such as HIC.

However, HIC technique requires skilled personnel for its proper implementation, which is a barrier to the widespread adoption of HIC due to the shortage of trained professionals in some regions. This lack of skilled labor hinders the widespread adoption and efficient use of HIC technologies. The need for extensive training and expertise in chromatography leads to longer setup times, operational delays, and increased costs, thereby limiting market growth.

On the other hand, ongoing technological innovations, such as improvements in chromatography resins and automation, have enhanced the scalability and cost-effectiveness of HIC, making it more accessible for large-scale production, which provides an opportunity for market growth. Government initiatives aimed at supporting biomanufacturing and strengthening healthcare infrastructure create favorable conditions for market growth.

The hydrophobic interaction chromatography market is segmented into product & service, sample type, application, end user, and region. By product & service, the market is bifurcated into product and service. The product segment is further categorized into resin, buffer, column, and others. The resin segment is further classified into beads and others. The column segment is further divided into pre-packed columns and empty columns. The pre-packed column segment is further categorized into disposable and reusable. By sample type, the market is segregated into monoclonal antibodies, vaccines, cell culture sample, plasma & serum sample, and others. By application, the market is fragmented into protein & antibody purification, vaccine development, drug discovery, and food & dietary supplement development. The protein and antibody purification segment is further categorized for resins into beads and others. By end user, the market is segregated into pharmaceutical & biopharmaceutical companies, contract research organizations & contract manufacturing organizations, research & academic institutes, and others.

Region wise, the market is analyzed across North America (U.S., Canada, and Mexico), Europe (Germany, France, UK, Italy, Spain, and rest of Europe), Asia-Pacific (Japan, China, India, Australia, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).

Major key players that operate in the global hydrophobic interaction chromatography market are Bio-Rad Laboratories, Inc., Sartorius AG, Thermo Fisher Scientific Inc., Tosoh Corporation, Danaher Corporation, Sepax Technologies, Inc., Agilent Technologies, Inc., Merck KGaA, Waters Corporation, and KNAUER Wissenschaftliche Geräte GmbH.

The key players operating in the market have adopted integration, product launch, contract, partnership, and expansion as their key strategies to expand their product portfolio. For instance, in July 2021, Cytiva and Pall Corporation, part of the Danaher Corporation, is expected to expand manufacturing capacity and services across regions for global life sciences customers. Cytiva and Pall Corporation have invested over $1.5 billion to expand their manufacturing capabilities for key products used in biologic medicine production. This includes over $600 million in chromatography resins, $400 million in cell culture media, $300 million in single-use technologies, and $200 million for global site expansions.

Key Benefits For Stakeholders

This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the hydrophobic interaction chromatography market analysis from 2023 to 2033 to identify the prevailing hydrophobic interaction chromatography market opportunities.
The market research is offered along with information related to key drivers, restraints, and opportunities.
Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
In-depth analysis of the hydrophobic interaction chromatography market segmentation assists to determine the prevailing market opportunities.
Major countries in each region are mapped according to their revenue contribution to the global market.
Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
The report includes the analysis of the regional as well as global hydrophobic interaction chromatography market trends, key players, market segments, application areas, and market growth strategies.

Key Market Segments

By Product and Service

Product
Type
Resin
Type
Buffer
Column
Type
Others
Service

By Sample type

Monoclonal antibodies
Vaccines
Cell culture sample
Plasma and serum sample
Others

By Application

Protein and antibody purification
Resins
Beads
Others
Vaccine development
Drug discovery
Food and dietary supplement development

By End user

Research and academic institutes
Others
Pharmaceutical and biopharmaceutical companies
Contract research organizations and contract manufacturing organizations

By Region

North America
U.S.
Canada
Mexico
Europe
Germany
France
UK
Italy
Spain
Rest of Europe
Asia-Pacific
Japan
China
India
Australia
South Korea
Rest of Asia-Pacific
LAMEA
Brazil
South Africa,
Saudi Arabia
Rest of LAMEA

Key Market Players

Sepax Technologies, Inc.
Tosoh Corporation
Agilent Technologies, Inc.
Thermo Fisher Scientific Inc.
Danaher Corporation
Merck KGaA
Geno Technology, Inc.
Waters Corporation
KNAUER Wissenschaftliche Gerate GmbH
Bio-Rad Laboratories, Inc.
Sartorius AG