The Global Plasmid DNA Manufacturing Market Size accounted for USD 1.9 Billion in 2023 and is estimated to achieve a market size of USD 10.5 Billion by 2032 growing at a CAGR of 20.9% from 2024 to 2032.
The plasmid DNA manufacturing market is experiencing rapid growth, driven by the increasing demand for gene therapies, vaccine development, and advancements in biotechnology research. Plasmid DNA (pDNA) is a small, circular piece of DNA that is commonly used in genetic research, biotechnology, and the production of therapeutic proteins and vaccines. Due to its versatility, stability, and ability to be replicated in bacterial cells, plasmid DNA plays a vital role in gene therapy applications, vaccine development, and the production of recombinant proteins. The market for plasmid DNA manufacturing is expected to expand significantly over the coming years as the demand for advanced biopharmaceuticals and personalized medicine grows, with an emphasis on cutting-edge gene therapies and DNA-based vaccines.
Plasmid DNA manufacturing involves the extraction, purification, and production of plasmid DNA from bacterial sources, which is then used in a variety of applications, including gene delivery systems, research on genetic disorders, vaccine production, and cell-based therapies. The key factors driving the growth of the plasmid DNA manufacturing market include the increasing adoption of gene therapies for the treatment of genetic diseases, the rising focus on cell and gene therapies in oncology, and the accelerating development of DNA-based vaccines, particularly in response to the COVID-19 pandemic.
Plasmid DNA Manufacturing Market Segmentation
The worldwide market for plasmid DNA manufacturing is split based on grade, disease, development phase, application, and geography.
Plasmid DNA Manufacturing Market By Grade
R&D Grade
Viral Vector Development
Lentivirus
AAV
Retrovirus
Adenovirus
Others
Antibody Development
mRNA Development
DNA Vaccine Development
Others
GMP Grade
Plasmid DNA Manufacturing D Market By Disease
Infectious Disease
Cancer
Genetic Disorder
Plasmid DNA Manufacturing Market By Development Phase
Clinical Therapeutics
Pre-Clinical Therapeutics
Marketed Therapeutics
Plasmid DNA Manufacturing Market By Application
DNA Vaccines
Cell & Gene Therapy
Immunotherapy
Others
Plasmid DNA Manufacturing Market Regional Outlook
North America
U.S.
Canada
Europe
U.K.
Germany
France
Spain
Rest of Europe
Asia-Pacific
India
Japan
China
Australia
South Korea
Rest of Asia-Pacific
Latin America
Brazil
Mexico
Rest of Latin America
The Middle East & Africa
South Africa
GCC Countries
Rest of the Middle East & Africa (ME&A)
Plasmid DNA Manufacturing Market Players
Some of the top plasmid DNA manufacturing market companies offered in our report includes Aldevron, Akron Biotech, VGXI, Inc., Nature Technology Corporation, Plasmidfactory GmbH, Cobra Biologics & Pharmaceutical Services, Vigene Biosciences, Luminous Biosciences, JAFRAL Ltd., and Delphi Genetics.
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- CHAPTER 1. Industry Overview of Plasmid DNA Manufacturing Market
- 1.1. Definition and Scope
- 1.2. Summary
- CHAPTER 2. Research Approach
- 2.1. Methodology
- 2.2. Data Source
- CHAPTER 3. Market Dynamics And Competition Analysis
- 3.1. Market Drivers
- 3.2. Restraints and Challenges
- 3.3. Growth Opportunities
- 3.4. Porter’s Five Forces Analysis
- 3.4.1. Bargaining Power of Suppliers
- 3.4.2. Bargaining Power of Buyers
- 3.4.3. Threat of Substitute
- 3.4.4. Threat of New Entrants
- 3.4.5. Degree of Competition
- 3.5. Market Concentration Ratio and Market Maturity Analysis of Plasmid DNA Manufacturing Market
- 3.5.1. Go To Market Strategy
- 3.5.1.1. Introduction
- 3.5.1.2. Growth
- 3.5.1.3. Maturity
- 3.5.1.4. Saturation
- 3.5.1.5. Possible Development
- 3.6. Technological Roadmap for Plasmid DNA Manufacturing Market
- 3.7. Value Chain Analysis
- 3.7.1. List of Key Manufacturers
- 3.7.2. List of Customers
- 3.7.3. Level of Integration
- 3.8. Regulatory Compliance
- 3.9. Competitive Landscape, 2023
- 3.9.1. Player Positioning Analysis
- 3.9.2. Key Strategies Adopted By Leading Players
- CHAPTER 4. Manufacturing Plant Analysis
- 4.1. Manufacturing Plant Location and Establish Date of Major Manufacturers in 2023
- 4.2. R&D Status of Major Manufacturers in 2023
- CHAPTER 5. Plasmid DNA Manufacturing Market By Grade
- 5.1. Introduction
- 5.2. Plasmid DNA Manufacturing Revenue By Grade
- 5.2.1. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast, By Grade, 2020-2032
- 5.2.2. R&D Grade
- 5.2.2.1. R&D Grade Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.2. Viral Vector Development
- 5.2.2.2.1. Viral Vector Development Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.2.2. Lentivirus
- 5.2.2.2.2.1. Lentivirus Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.2.3. AAV
- 5.2.2.2.3.1. AAV Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.2.4. Retrovirus
- 5.2.2.2.4.1. Retrovirus Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.2.5. Adenovirus
- 5.2.2.2.5.1. Adenovirus Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.2.6. Others
- 5.2.2.2.6.1. Others Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.3. Antibody Development
- 5.2.2.3.1. Antibody Development Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.4. mRNA Development
- 5.2.2.4.1. mRNA Development Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.5. DNA Vaccine Development
- 5.2.2.5.1. DNA Vaccine Development Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.2.6. Others
- 5.2.2.6.1. Others Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 5.2.3. GMP Grade
- 5.2.3.1. GMP Grade Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- CHAPTER 6. Plasmid DNA Manufacturing Market By Disease
- 6.1. Introduction
- 6.2. Plasmid DNA Manufacturing Revenue By Disease
- 6.2.1. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast, By Disease, 2020-2032
- 6.2.2. Infectious Disease
- 6.2.2.1. Infectious Disease Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 6.2.3. Cancer
- 6.2.3.1. Cancer Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 6.2.4. Genetic Disorder
- 6.2.4.1. Genetic Disorder Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- CHAPTER 7. Plasmid DNA Manufacturing Market By Development Phase
- 7.1. Introduction
- 7.2. Plasmid DNA Manufacturing Revenue By Development Phase
- 7.2.1. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast, By Development Phase, 2020-2032
- 7.2.2. Clinical Therapeutics
- 7.2.2.1. Clinical Therapeutics Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 7.2.3. Pre-Clinical Therapeutics
- 7.2.3.1. Pre-Clinical Therapeutics Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 7.2.4. Marketed Therapeutics
- 7.2.4.1. Marketed Therapeutics Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- CHAPTER 8. Plasmid DNA Manufacturing Market By Application
- 8.1. Introduction
- 8.2. Plasmid DNA Manufacturing Revenue By Application
- 8.2.1. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast, By Application, 2020-2032
- 8.2.2. DNA Vaccines
- 8.2.2.1. DNA Vaccines Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 8.2.3. Cell & Gene Therapy
- 8.2.3.1. Cell & Gene Therapy Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 8.2.4. Immunotherapy
- 8.2.4.1. Immunotherapy Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- 8.2.5. Others
- 8.2.5.1. Others Market Revenue (USD Million) and Growth Rate (%), 2020-2032
- CHAPTER 9. North America Plasmid DNA Manufacturing Market By Country
- 9.1. North America Plasmid DNA Manufacturing Market Overview
- 9.2. U.S.
- 9.2.1. U.S. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 9.2.2. U.S. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 9.2.3. U.S. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 9.2.4. U.S. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 9.3. Canada
- 9.3.1. Canada Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 9.3.2. Canada Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 9.3.3. Canada Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 9.3.4. Canada Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 9.4. North America PEST Analysis
- CHAPTER 10. Europe Plasmid DNA Manufacturing Market By Country
- 10.1. Europe Plasmid DNA Manufacturing Market Overview
- 10.2. U.K.
- 10.2.1. U.K. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 10.2.2. U.K. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 10.2.3. U.K. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 10.2.4. U.K. Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 10.3. Germany
- 10.3.1. Germany Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 10.3.2. Germany Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 10.3.3. Germany Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 10.3.4. Germany Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 10.4. France
- 10.4.1. France Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 10.4.2. France Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 10.4.3. France Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 10.4.4. France Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 10.5. Spain
- 10.5.1. Spain Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 10.5.2. Spain Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 10.5.3. Spain Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 10.5.4. Spain Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 10.6. Rest of Europe
- 10.6.1. Rest of Europe Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 10.6.2. Rest of Europe Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 10.6.3. Rest of Europe Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 10.6.4. Rest of Europe Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 10.7. Europe PEST Analysis
- CHAPTER 11. Asia Pacific Plasmid DNA Manufacturing Market By Country
- 11.1. Asia Pacific Plasmid DNA Manufacturing Market Overview
- 11.2. China
- 11.2.1. China Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 11.2.2. China Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 11.2.3. China Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 11.2.4. China Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 11.3. Japan
- 11.3.1. Japan Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 11.3.2. Japan Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 11.3.3. Japan Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 11.3.4. Japan Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 11.4. India
- 11.4.1. India Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 11.4.2. India Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 11.4.3. India Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 11.4.4. India Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 11.5. Australia
- 11.5.1. Australia Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 11.5.2. Australia Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 11.5.3. Australia Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 11.5.4. Australia Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 11.6. South Korea
- 11.6.1. South Korea Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 11.6.2. South Korea Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 11.6.3. South Korea Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 11.6.4. South Korea Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 11.7. Rest of Asia-Pacific
- 11.7.1. Rest of Asia-Pacific Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 11.7.2. Rest of Asia-Pacific Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 11.7.3. Rest of Asia-Pacific Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 11.7.4. Rest of Asia-Pacific Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 11.8. Asia Pacific PEST Analysis
- CHAPTER 12. Latin America Plasmid DNA Manufacturing Market By Country
- 12.1. Latin America Plasmid DNA Manufacturing Market Overview
- 12.2. Brazil
- 12.2.1. Brazil Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 12.2.2. Brazil Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 12.2.3. Brazil Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 12.2.4. Brazil Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 12.3. Mexico
- 12.3.1. Mexico Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 12.3.2. Mexico Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 12.3.3. Mexico Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 12.3.4. Mexico Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 12.4. Rest of Latin America
- 12.4.1. Rest of Latin America Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 12.4.2. Rest of Latin America Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 12.4.3. Rest of Latin America Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 12.4.4. Rest of Latin America Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 12.5. Latin America PEST Analysis
- CHAPTER 13. Middle East & Africa Plasmid DNA Manufacturing Market By Country
- 13.1. Middle East & Africa Plasmid DNA Manufacturing Market Overview
- 13.2. GCC
- 13.2.1. GCC Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 13.2.2. GCC Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 13.2.3. GCC Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 13.2.4. GCC Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 13.3. South Africa
- 13.3.1. South Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 13.3.2. South Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 13.3.3. South Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 13.3.4. South Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 13.4. Rest of Middle East & Africa
- 13.4.1. Rest of Middle East & Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Disease, 2020-2032
- 13.4.2. Rest of Middle East & Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Grade, 2020-2032
- 13.4.3. Rest of Middle East & Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Development Phase, 2020-2032
- 13.4.4. Rest of Middle East & Africa Plasmid DNA Manufacturing Revenue (USD Million) and Forecast By Application, 2020-2032
- 13.5. Middle East & Africa PEST Analysis
- CHAPTER 14. Player Analysis Of Plasmid DNA Manufacturing Market
- 14.1. Plasmid DNA Manufacturing Market Company Share Analysis
- 14.2. Competition Matrix
- 14.2.1. Competitive Benchmarking of key players by price, presence, market share, and R&D investment
- 14.2.2. New Product Launches and Product Enhancements
- 14.2.3. Mergers And Acquisition In Global Plasmid DNA Manufacturing Market
- 14.2.4. Partnership, Joint Ventures and Strategic Alliances/ Sales Agreements
- CHAPTER 15. Company Profile
- 15.1. Aldevron
- 15.1.1. Company Snapshot
- 15.1.2. Business Overview
- 15.1.3. Financial Overview
- 15.1.3.1. Revenue (USD Million), 2023
- 15.1.3.2. Aldevron 2023 Plasmid DNA Manufacturing Business Regional Distribution
- 15.1.4. Product /Service and Specification
- 15.1.5. Recent Developments & Business Strategy
- 15.2. Akron Biotech
- 15.3. VGXI, Inc.
- 15.4. Nature Technology Corporation
- 15.5. Plasmidfactory GmbH
- 15.6. Cobra Biologics & Pharmaceutical Services
- 15.7. Vigene Biosciences
- 15.8. Luminous Biosciences
- 15.9. JAFRAL Ltd.
- 15.10. Delphi Genetics
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