Global Methotrexate Industry Growth and Trends Forecast to 2031

Summary

Methotrexate is kwon as Amethopterin, Methotrexate Sodium, and MTX. It is a yellow or orange, crystalline powder, and made into methotrexate tablets and methotrexate for injection.

Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis.

According to APO Research, The global Methotrexate market was estimated at US$ million in 2025 and is projected to reach a revised size of US$ million by 2031, witnessing a CAGR of xx% during the forecast period 2026-2031.

North American market for Methotrexate is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2026 through 2031.

Asia-Pacific market for Methotrexate is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2026 through 2031.

Europe market for Methotrexate is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2026 through 2031.

The major global manufacturers of Methotrexate include Teva Pharmaceutical Industries, Qualitestrx (DAVA Pharmaceuticals), Pfizer (Hospira), Roxane Laboratories, Sine, Maoxiang, LingNan Pharmaceutical, Powerdone and Huiyu, etc. In 2024, the world's top three vendors accounted for approximately % of the revenue.

Report Scope

This report aims to provide a comprehensive presentation of the global market for Methotrexate, with both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding Methotrexate.

The Methotrexate market size, estimations, and forecasts are provided in terms of sales volume (Kg) and revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. This report segments the global Methotrexate market comprehensively. Regional market sizes, concerning products by Type, by Application, and by players, are also provided. For a more in-depth understanding of the market, the report provides profiles of the competitive landscape, key competitors, and their respective market ranks. The report also discusses technological trends and new product developments.

Key Companies & Market Share Insights

In this section, the readers will gain an understanding of the key players competing. This report has studied the key growth strategies, such as innovative trends and developments, intensification of product portfolio, mergers and acquisitions, collaborations, new product innovation, and geographical expansion, undertaken by these participants to maintain their presence. Apart from business strategies, the study includes current developments and key financials. The readers will also get access to the data related to global revenue, price, and sales by manufacturers for the period 2020-2025. This all-inclusive report will certainly serve the clients to stay updated and make effective decisions in their businesses.

Methotrexate Segment by Company

Teva Pharmaceutical Industries
Qualitestrx (DAVA Pharmaceuticals)
Pfizer (Hospira)
Roxane Laboratories
Sine
Maoxiang
LingNan Pharmaceutical
Powerdone
Huiyu

Methotrexate Segment by Type

Methotrexate for Injection
Methotrexate Tablets

Methotrexate Segment by Application

Used for Cancers
Used for Rheumatoid Arthritis
Used for Other Diseases

Methotrexate Segment by Region

North America
United States
Canada
Mexico
Europe
Germany
France
U.K.
Italy
Russia
Spain
Netherlands
Switzerland
Sweden
Poland
Asia-Pacific
China
Japan
South Korea
India
Australia
Taiwan
Southeast Asia
South America
Brazil
Argentina
Chile
Middle East & Africa
Egypt
South Africa
Israel
Türkiye
GCC Countries

Key Drivers & Barriers

High-impact rendering factors and drivers have been studied in this report to aid the readers to understand the general development. Moreover, the report includes restraints and challenges that may act as stumbling blocks on the way of the players. This will assist the users to be attentive and make informed decisions related to business. Specialists have also laid their focus on the upcoming business prospects.

Reasons to Buy This Report

1. This report will help the readers to understand the competition within the industries and strategies for the competitive environment to enhance the potential profit. The report also focuses on the competitive landscape of the global Methotrexate market, and introduces in detail the market share, industry ranking, competitor ecosystem, market performance, new product development, operation situation, expansion, and acquisition. etc. of the main players, which helps the readers to identify the main competitors and deeply understand the competition pattern of the market.
2. This report will help stakeholders to understand the global industry status and trends of Methotrexate and provides them with information on key market drivers, restraints, challenges, and opportunities.
3. This report will help stakeholders to understand competitors better and gain more insights to strengthen their position in their businesses. The competitive landscape section includes the market share and rank (in volume and value), competitor ecosystem, new product development, expansion, and acquisition.
4. This report stays updated with novel technology integration, features, and the latest developments in the market
5. This report helps stakeholders to gain insights into which regions to target globally
6. This report helps stakeholders to gain insights into the end-user perception concerning the adoption of Methotrexate.
7. This report helps stakeholders to identify some of the key players in the market and understand their valuable contribution.

Chapter Outline

Chapter 1: Introduces the study scope of this report, executive summary of market segments by type, market size segments for North America, Europe, Asia Pacific, South America, Middle East & Africa.
Chapter 2: Introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 3: Detailed analysis of Methotrexate manufacturers competitive landscape, price, sales, revenue, market share and ranking, latest development plan, merger, and acquisition information, etc.
Chapter 4: Sales, revenue of Methotrexate in regional level. It provides a quantitative analysis of the market size and development potential of each region and introduces the future development prospects, and market space in the world.
Chapter 5: Introduces market segments by application, market size segment for North America, Europe, Asia Pacific, South America, Middle East & Africa.
Chapter 6: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product sales, revenue, price, gross margin, product introduction, recent development, etc.
Chapter 7, 8, 9, 10 and 11: North America, Europe, Asia Pacific, South America, Middle East & Africa, sales and revenue by country.
Chapter 12: Analysis of industrial chain, key raw materials, manufacturing cost, and market dynamics.
Chapter 13: Concluding Insights of the report.

Please Note: Single-User license will be delivered via PDF from the publisher without the rights to print or to edit.


1 Market Overview

1.1 Product Definition
1.2 Global Market Growth Prospects
1.2.1 Global Methotrexate Market Size Estimates and Forecasts (2020-2031)
1.2.2 Global Methotrexate Sales Estimates and Forecasts (2020-2031)
1.3 Methotrexate Market by Type
1.3.1 Methotrexate for Injection
1.3.2 Methotrexate Tablets
1.4 Global Methotrexate Market Size by Type
1.4.1 Global Methotrexate Market Size Overview by Type (2020-2031)
1.4.2 Global Methotrexate Historic Market Size Review by Type (2020-2025)
1.4.3 Global Methotrexate Forecasted Market Size by Type (2026-2031)
1.5 Key Regions Market Size by Type
1.5.1 North America Methotrexate Sales Breakdown by Type (2020-2025)
1.5.2 Europe Methotrexate Sales Breakdown by Type (2020-2025)
1.5.3 Asia-Pacific Methotrexate Sales Breakdown by Type (2020-2025)
1.5.4 South America Methotrexate Sales Breakdown by Type (2020-2025)
1.5.5 Middle East and Africa Methotrexate Sales Breakdown by Type (2020-2025)
2 Global Market Dynamics

2.1 Methotrexate Industry Trends
2.2 Methotrexate Industry Drivers
2.3 Methotrexate Industry Opportunities and Challenges
2.4 Methotrexate Industry Restraints
3 Market Competitive Landscape by Company

3.1 Global Top Players by Methotrexate Revenue (2020-2025)
3.2 Global Top Players by Methotrexate Sales (2020-2025)
3.3 Global Top Players by Methotrexate Price (2020-2025)
3.4 Global Methotrexate Industry Company Ranking, 2023 VS 2024 VS 2025
3.5 Global Methotrexate Major Company Production Sites & Headquarters
3.6 Global Methotrexate Company, Product Type & Application
3.7 Global Methotrexate Company Establishment Date
3.8 Market Competitive Analysis
3.8.1 Global Methotrexate Market CR5 and HHI
3.8.2 Global Top 5 and 10 Methotrexate Players Market Share by Revenue in 2024
3.8.3 2023 Methotrexate Tier 1, Tier 2, and Tier 3
4 Methotrexate Regional Status and Outlook

4.1 Global Methotrexate Market Size and CAGR by Region: 2020 VS 2024 VS 2031
4.2 Global Methotrexate Historic Market Size by Region
4.2.1 Global Methotrexate Sales in Volume by Region (2020-2025)
4.2.2 Global Methotrexate Sales in Value by Region (2020-2025)
4.2.3 Global Methotrexate Sales (Volume & Value), Price and Gross Margin (2020-2025)
4.3 Global Methotrexate Forecasted Market Size by Region
4.3.1 Global Methotrexate Sales in Volume by Region (2026-2031)
4.3.2 Global Methotrexate Sales in Value by Region (2026-2031)
4.3.3 Global Methotrexate Sales (Volume & Value), Price and Gross Margin (2026-2031)
5 Methotrexate by Application

5.1 Methotrexate Market by Application
5.1.1 Used for Cancers
5.1.2 Used for Rheumatoid Arthritis
5.1.3 Used for Other Diseases
5.2 Global Methotrexate Market Size by Application
5.2.1 Global Methotrexate Market Size Overview by Application (2020-2031)
5.2.2 Global Methotrexate Historic Market Size Review by Application (2020-2025)
5.2.3 Global Methotrexate Forecasted Market Size by Application (2026-2031)
5.3 Key Regions Market Size by Application
5.3.1 North America Methotrexate Sales Breakdown by Application (2020-2025)
5.3.2 Europe Methotrexate Sales Breakdown by Application (2020-2025)
5.3.3 Asia-Pacific Methotrexate Sales Breakdown by Application (2020-2025)
5.3.4 South America Methotrexate Sales Breakdown by Application (2020-2025)
5.3.5 Middle East and Africa Methotrexate Sales Breakdown by Application (2020-2025)
6 Company Profiles

6.1 Teva Pharmaceutical Industries
6.1.1 Teva Pharmaceutical Industries Comapny Information
6.1.2 Teva Pharmaceutical Industries Business Overview
6.1.3 Teva Pharmaceutical Industries Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.1.4 Teva Pharmaceutical Industries Methotrexate Product Portfolio
6.1.5 Teva Pharmaceutical Industries Recent Developments
6.2 Qualitestrx (DAVA Pharmaceuticals)
6.2.1 Qualitestrx (DAVA Pharmaceuticals) Comapny Information
6.2.2 Qualitestrx (DAVA Pharmaceuticals) Business Overview
6.2.3 Qualitestrx (DAVA Pharmaceuticals) Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.2.4 Qualitestrx (DAVA Pharmaceuticals) Methotrexate Product Portfolio
6.2.5 Qualitestrx (DAVA Pharmaceuticals) Recent Developments
6.3 Pfizer (Hospira)
6.3.1 Pfizer (Hospira) Comapny Information
6.3.2 Pfizer (Hospira) Business Overview
6.3.3 Pfizer (Hospira) Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.3.4 Pfizer (Hospira) Methotrexate Product Portfolio
6.3.5 Pfizer (Hospira) Recent Developments
6.4 Roxane Laboratories
6.4.1 Roxane Laboratories Comapny Information
6.4.2 Roxane Laboratories Business Overview
6.4.3 Roxane Laboratories Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.4.4 Roxane Laboratories Methotrexate Product Portfolio
6.4.5 Roxane Laboratories Recent Developments
6.5 Sine
6.5.1 Sine Comapny Information
6.5.2 Sine Business Overview
6.5.3 Sine Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.5.4 Sine Methotrexate Product Portfolio
6.5.5 Sine Recent Developments
6.6 Maoxiang
6.6.1 Maoxiang Comapny Information
6.6.2 Maoxiang Business Overview
6.6.3 Maoxiang Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.6.4 Maoxiang Methotrexate Product Portfolio
6.6.5 Maoxiang Recent Developments
6.7 LingNan Pharmaceutical
6.7.1 LingNan Pharmaceutical Comapny Information
6.7.2 LingNan Pharmaceutical Business Overview
6.7.3 LingNan Pharmaceutical Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.7.4 LingNan Pharmaceutical Methotrexate Product Portfolio
6.7.5 LingNan Pharmaceutical Recent Developments
6.8 Powerdone
6.8.1 Powerdone Comapny Information
6.8.2 Powerdone Business Overview
6.8.3 Powerdone Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.8.4 Powerdone Methotrexate Product Portfolio
6.8.5 Powerdone Recent Developments
6.9 Huiyu
6.9.1 Huiyu Comapny Information
6.9.2 Huiyu Business Overview
6.9.3 Huiyu Methotrexate Sales, Revenue and Gross Margin (2020-2025)
6.9.4 Huiyu Methotrexate Product Portfolio
6.9.5 Huiyu Recent Developments
7 North America by Country

7.1 North America Methotrexate Sales by Country
7.1.1 North America Methotrexate Sales Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
7.1.2 North America Methotrexate Sales by Country (2020-2025)
7.1.3 North America Methotrexate Sales Forecast by Country (2026-2031)
7.2 North America Methotrexate Market Size by Country
7.2.1 North America Methotrexate Market Size Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
7.2.2 North America Methotrexate Market Size by Country (2020-2025)
7.2.3 North America Methotrexate Market Size Forecast by Country (2026-2031)
8 Europe by Country

8.1 Europe Methotrexate Sales by Country
8.1.1 Europe Methotrexate Sales Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
8.1.2 Europe Methotrexate Sales by Country (2020-2025)
8.1.3 Europe Methotrexate Sales Forecast by Country (2026-2031)
8.2 Europe Methotrexate Market Size by Country
8.2.1 Europe Methotrexate Market Size Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
8.2.2 Europe Methotrexate Market Size by Country (2020-2025)
8.2.3 Europe Methotrexate Market Size Forecast by Country (2026-2031)
9 Asia-Pacific by Country

9.1 Asia-Pacific Methotrexate Sales by Country
9.1.1 Asia-Pacific Methotrexate Sales Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
9.1.2 Asia-Pacific Methotrexate Sales by Country (2020-2025)
9.1.3 Asia-Pacific Methotrexate Sales Forecast by Country (2026-2031)
9.2 Asia-Pacific Methotrexate Market Size by Country
9.2.1 Asia-Pacific Methotrexate Market Size Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
9.2.2 Asia-Pacific Methotrexate Market Size by Country (2020-2025)
9.2.3 Asia-Pacific Methotrexate Market Size Forecast by Country (2026-2031)
10 South America by Country

10.1 South America Methotrexate Sales by Country
10.1.1 South America Methotrexate Sales Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
10.1.2 South America Methotrexate Sales by Country (2020-2025)
10.1.3 South America Methotrexate Sales Forecast by Country (2026-2031)
10.2 South America Methotrexate Market Size by Country
10.2.1 South America Methotrexate Market Size Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
10.2.2 South America Methotrexate Market Size by Country (2020-2025)
10.2.3 South America Methotrexate Market Size Forecast by Country (2026-2031)
11 Middle East and Africa by Country

11.1 Middle East and Africa Methotrexate Sales by Country
11.1.1 Middle East and Africa Methotrexate Sales Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
11.1.2 Middle East and Africa Methotrexate Sales by Country (2020-2025)
11.1.3 Middle East and Africa Methotrexate Sales Forecast by Country (2026-2031)
11.2 Middle East and Africa Methotrexate Market Size by Country
11.2.1 Middle East and Africa Methotrexate Market Size Growth Rate (CAGR) by Country: 2020 VS 2024 VS 2031
11.2.2 Middle East and Africa Methotrexate Market Size by Country (2020-2025)
11.2.3 Middle East and Africa Methotrexate Market Size Forecast by Country (2026-2031)
12 Value Chain and Sales Channels Analysis

12.1 Methotrexate Value Chain Analysis
12.1.1 Methotrexate Key Raw Materials
12.1.2 Key Raw Materials Price
12.1.3 Raw Materials Key Suppliers
12.1.4 Manufacturing Cost Structure
12.1.5 Methotrexate Production Mode & Process
12.2 Methotrexate Sales Channels Analysis
12.2.1 Direct Comparison with Distribution Share
12.2.2 Methotrexate Distributors
12.2.3 Methotrexate Customers
13 Concluding Insights
14 Appendix

14.1 Reasons for Doing This Study
14.2 Research Methodology
14.3 Research Process
14.4 Authors List of This Report
14.5 Data Source
14.5.1 Secondary Sources
14.5.2 Primary Sources
14.6 Disclaimer

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