Rare Disease Genetic Testing Market by Disease Type (Cancer, Cardiovascular Disorders, Dermatology Diseases), Technology (Array Technology, FISH, Karyotyping), Specialty, End-User - Global Forecast 2024-2030

Rare Disease Genetic Testing Market by Disease Type (Cancer, Cardiovascular Disorders, Dermatology Diseases), Technology (Array Technology, FISH, Karyotyping), Specialty, End-User - Global Forecast 2024-2030


The Rare Disease Genetic Testing Market size was estimated at USD 1.33 billion in 2023 and expected to reach USD 1.54 billion in 2024, at a CAGR 16.15% to reach USD 3.80 billion by 2030.

Rare disease genetic testing refers to the process of analyzing DNA, RNA, chromosomes, proteins, or certain metabolites to identify genetic mutations or abnormalities that may lead to a rare disease. Since rare diseases are predominantly genetic in origin, such tests are pivotal for early and accurate diagnosis. Advances in genomic technologies have significantly reduced the cost and increased the speed and accuracy of genetic tests. Moreover, there is a growing awareness and understanding of the importance of early and precise diagnosis in managing rare diseases, which has led to a rise in demand for these tests. However, the possibility of uncertain or ambiguous results and issues related to privacy, and the potential for genetic discrimination impact the utility of genetic testing. To address these issues, stringent guidelines and regulations must be enforced to ensure the privacy and ethical conduct of genetic testing. With ongoing scientific advancements, the development of more sophisticated and comprehensive testing methods, such as next-generation sequencing, is on the horizon. Additionally, there is an increasing trend toward consumer-driven healthcare, which may bolster the market for direct-to-consumer genetic testing kits.

Regional Insights

The Americas exhibit a robust genetic testing infrastructure and a high awareness level among healthcare providers and patients, bolstered by a strong presence of leading companies and supportive regulatory frameworks. Reimbursement policies and investments in rare disease research contribute to the widespread use and production of genetic tests. The APAC region, while rapidly growing, reveals disparities in access and adoption of rare disease genetic testing. Japan and Australia lead with advancements in technology and increasing government support. Collaborations with global entities shape the production and use in this region, and a growing number of local players are investing in R&D. Meanwhile, the EMEA region presents a diverse landscape; Western Europe mirrors the Americas in terms of technology adoption and production capabilities, with well-established companies driving growth. The EU's regulations, including GDPR, impact genetic data usage, having both positive and negative implications on the market. The Middle East and Africa are nascent markets where awareness is gradually increasing. Genetic testing in these areas is sporadically utilized, primarily facilitated by international aid and partnerships. Companies range from large multinational diagnostics firms to specialized biotechs focused on rare disease genetics in this region.

Market Insights
  • Market Dynamics

    The market dynamics represent an ever-changing landscape of the Rare Disease Genetic Testing Market by providing actionable insights into factors, including supply and demand levels. Accounting for these factors helps design strategies, make investments, and formulate developments to capitalize on future opportunities. In addition, these factors assist in avoiding potential pitfalls related to political, geographical, technical, social, and economic conditions, highlighting consumer behaviors and influencing manufacturing costs and purchasing decisions.
    • Market Drivers
      • Prevalence of Rare Genetic Disease and Need for Early & Rapid Diagnosis
      • Rising Use in Translational & Genomic Research for Identification of Novel Mutations
      • Government Initiatives for Diagnosis and Treatment of Rare Diseases
      • Market Restraints
        • Ethical Concerns and Access to Limited Information on Rare Disease
        • Market Opportunities
          • Advancements in Genetic Technology to Identify New Rare Disease Genes
          • Favorable Investments for Diagnosis of Rare Genetic Diseases
          • Market Challenges
            • Stringent Regulations Associated with the Approval Process of New Rare Diseases Genetic Test
            • Market Segmentation Analysis
              • Disease Type: Development of advanced tests to cater to the screening needs of rare genetic diseases
              • End-User: Emerging studies on rare genetic testing in research laboratories in academic institutes
              • Market Disruption Analysis
              • Porter’s Five Forces Analysis
              • Value Chain & Critical Path Analysis
              • Pricing Analysis
              • Technology Analysis
              • Patent Analysis
              • Trade Analysis
              • Regulatory Framework Analysis
              FPNV Positioning Matrix

              The FPNV positioning matrix is essential in evaluating the market positioning of the vendors in the Rare Disease Genetic Testing Market. This matrix offers a comprehensive assessment of vendors, examining critical metrics related to business strategy and product satisfaction. This in-depth assessment empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success, namely Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

              Market Share Analysis

              The market share analysis is a comprehensive tool that provides an insightful and in-depth assessment of the current state of vendors in the Rare Disease Genetic Testing Market. By meticulously comparing and analyzing vendor contributions, companies are offered a greater understanding of their performance and the challenges they face when competing for market share. These contributions include overall revenue, customer base, and other vital metrics. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With these illustrative details, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

              Recent Developments
              • Burjeel Holdings To Launch Rare Disease Research & Development Project ‘Nader’ In Partnership With US-Based Bridgebio Pharma

                Burjeel Holdings and BridgeBio Pharma, a biopharmaceutical company dedicated to the discovery of treatments for genetic diseases and cancers, have forged a partnership through a preliminary Collaboration Agreement to initiate project 'NADER'—a pioneering initiative in the United Arab Emirates. This project, whose name means 'rare' in Arabic, is set to transform early detection and therapy for rare, often genetic disorders that are typically life-long and may be life-threatening or debilitating.

                NIH Launches USD 140 Million Effort To Investigate Genetic Variation In Normal Human Cells And Tissues

                The National Institutes of Health announced the inception of the Common Fund’s Somatic Mosaicism Across Human Tissues (SMaHT) Network. This innovative initiative is dedicated to advancing our understanding of the extent of genetic variation across various human tissues. The program is positioned to engender a paradigm shift in the detection and treatment of rare genetic disorders, by enabling a deeper insight into the genetic diversity within individuals.

                CENTOGENE Launches NEW CentoGenome, A Whole Genome Sequencing Solution for Diagnosis of Rare and Neurodegenerative Diseases

                Centogene N.V., a partner for data-driven solutions in rare and neurodegenerative disorders, unveiled its pioneering NEXT CentoGenome assay, an enhanced whole genome sequencing (WGS) tool. Its novel design excludes Polymerase Chain Reaction (PCR), mitigating typical biases and resulting in enriched sequencing data. NEW CentoGenome propels the quest for thorough diagnosis and personalized treatment strategies with unparalleled sensitivity and coverage, marking a significant stride in the landscape of genetic healthcare.
              Strategy Analysis & Recommendation

              The strategic analysis is essential for organizations seeking a solid foothold in the global marketplace. Companies are better positioned to make informed decisions that align with their long-term aspirations by thoroughly evaluating their current standing in the Rare Disease Genetic Testing Market. This critical assessment involves a thorough analysis of the organization’s resources, capabilities, and overall performance to identify its core strengths and areas for improvement.

              Key Company Profiles

              The report delves into recent significant developments in the Rare Disease Genetic Testing Market, highlighting leading vendors and their innovative profiles. These include 3billion, Inc., Ambry Genetics Corporation, Arup Laboratories, Baylor Genetics, Biora Therapeutics, Inc., Blueprint Genetics Oy, Caris Life Sciences, Centogene N.V., Color Health, Inc., F. Hoffmann-La Roche Ltd., Fulgent Genetics, Inc., GeneDx, LLC, Genomelink, Inc., Helix OpCo, LLC, Illumina, Inc., Integrated DNA Technologies, Inc. by Danaher Corporation, Invitae Corporation, Laboratory Corporation Of America Holdings, Macrogen, Inc., Myriad Genetics, Inc., Nonacus Limited, OPKO Health, Inc., PerkinElmer Inc., QIAGEN N.V., Quest Diagnostics Incorporated, Realm IDX, Inc., Sanofi S.A., The Cooper Companies, Inc., Thermo Fisher Scientific Inc., and Variantyx, Inc..

              Market Segmentation & Coverage

              This research report categorizes the Rare Disease Genetic Testing Market to forecast the revenues and analyze trends in each of the following sub-markets:
              • Disease Type
                • Cancer
                • Cardiovascular Disorders
                • Dermatology Diseases
                • Endocrine & Metabolism Diseases
                • Hematology Diseases
                • Immunological Disorders
                • Musculoskeletal Disorders
                • Neurological Disorders
                • Technology
                  • Array Technology
                  • FISH
                  • Karyotyping
                  • Next Generation Sequencing
                    • Whole Exome Sequencing
                    • Whole Genome Sequencing
                    • PCR - Based Testing
                    • Sanger Sequencing
                    • Specialty
                      • Biochemical Genetic Tests
                      • Chromosomal Genetic Tests
                      • Molecular Genetic Tests
                      • End-User
                        • Diagnostic Laboratories
                        • Hospitals & Clinics
                        • Research Laboratories & CROs
                        • Region
                          • Americas
                            • Argentina
                            • Brazil
                            • Canada
                            • Mexico
                            • United States
                              • California
                              • Florida
                              • Illinois
                              • New York
                              • Ohio
                              • Pennsylvania
                              • Texas
                              • Asia-Pacific
                                • Australia
                                • China
                                • India
                                • Indonesia
                                • Japan
                                • Malaysia
                                • Philippines
                                • Singapore
                                • South Korea
                                • Taiwan
                                • Thailand
                                • Vietnam
                                • Europe, Middle East & Africa
                                  • Denmark
                                  • Egypt
                                  • Finland
                                  • France
                                  • Germany
                                  • Israel
                                  • Italy
                                  • Netherlands
                                  • Nigeria
                                  • Norway
                                  • Poland
                                  • Qatar
                                  • Russia
                                  • Saudi Arabia
                                  • South Africa
                                  • Spain
                                  • Sweden
                                  • Switzerland
                                  • Turkey
                                  • United Arab Emirates
                                  • United Kingdom


                                  Please Note: PDF & Excel + Online Access - 1 Year


1. Preface
1.1. Objectives of the Study
1.2. Market Segmentation & Coverage
1.3. Years Considered for the Study
1.4. Currency & Pricing
1.5. Language
1.6. Stakeholders
2. Research Methodology
2.1. Define: Research Objective
2.2. Determine: Research Design
2.3. Prepare: Research Instrument
2.4. Collect: Data Source
2.5. Analyze: Data Interpretation
2.6. Formulate: Data Verification
2.7. Publish: Research Report
2.8. Repeat: Report Update
3. Executive Summary
4. Market Overview
5. Market Insights
5.1. Market Dynamics
5.1.1. Drivers
5.1.1.1. Prevalence of Rare Genetic Disease and Need for Early & Rapid Diagnosis
5.1.1.2. Rising Use in Translational & Genomic Research for Identification of Novel Mutations
5.1.1.3. Government Initiatives for Diagnosis and Treatment of Rare Diseases
5.1.2. Restraints
5.1.2.1. Ethical Concerns and Access to Limited Information on Rare Disease
5.1.3. Opportunities
5.1.3.1. Advancements in Genetic Technology to Identify New Rare Disease Genes
5.1.3.2. Favorable Investments for Diagnosis of Rare Genetic Diseases
5.1.4. Challenges
5.1.4.1. Stringent Regulations Associated with the Approval Process of New Rare Diseases Genetic Test
5.2. Market Segmentation Analysis
5.2.1. Disease Type: Development of advanced tests to cater to the screening needs of rare genetic diseases
5.2.2. End-User: Emerging studies on rare genetic testing in research laboratories in academic institutes
5.3. Market Trend Analysis
5.4. Cumulative Impact of Russia-Ukraine Conflict
5.5. Cumulative Impact of High Inflation
5.6. Porter’s Five Forces Analysis
5.6.1. Threat of New Entrants
5.6.2. Threat of Substitutes
5.6.3. Bargaining Power of Customers
5.6.4. Bargaining Power of Suppliers
5.6.5. Industry Rivalry
5.7. Value Chain & Critical Path Analysis
5.8. Regulatory Framework Analysis
5.9. Client Customization
6. Rare Disease Genetic Testing Market, by Disease Type
6.1. Introduction
6.2. Cancer
6.3. Cardiovascular Disorders
6.4. Dermatology Diseases
6.5. Endocrine & Metabolism Diseases
6.6. Hematology Diseases
6.7. Immunological Disorders
6.8. Musculoskeletal Disorders
6.9. Neurological Disorders
7. Rare Disease Genetic Testing Market, by Technology
7.1. Introduction
7.2. Array Technology
7.3. FISH
7.4. Karyotyping
7.5. Next Generation Sequencing
7.6. PCR - Based Testing
7.7. Sanger Sequencing
8. Rare Disease Genetic Testing Market, by Specialty
8.1. Introduction
8.2. Biochemical Genetic Tests
8.3. Chromosomal Genetic Tests
8.4. Molecular Genetic Tests
9. Rare Disease Genetic Testing Market, by End-User
9.1. Introduction
9.2. Diagnostic Laboratories
9.3. Hospitals & Clinics
9.4. Research Laboratories & CROs
10. Americas Rare Disease Genetic Testing Market
10.1. Introduction
10.2. Argentina
10.3. Brazil
10.4. Canada
10.5. Mexico
10.6. United States
11. Asia-Pacific Rare Disease Genetic Testing Market
11.1. Introduction
11.2. Australia
11.3. China
11.4. India
11.5. Indonesia
11.6. Japan
11.7. Malaysia
11.8. Philippines
11.9. Singapore
11.10. South Korea
11.11. Taiwan
11.12. Thailand
11.13. Vietnam
12. Europe, Middle East & Africa Rare Disease Genetic Testing Market
12.1. Introduction
12.2. Denmark
12.3. Egypt
12.4. Finland
12.5. France
12.6. Germany
12.7. Israel
12.8. Italy
12.9. Netherlands
12.10. Nigeria
12.11. Norway
12.12. Poland
12.13. Qatar
12.14. Russia
12.15. Saudi Arabia
12.16. South Africa
12.17. Spain
12.18. Sweden
12.19. Switzerland
12.20. Turkey
12.21. United Arab Emirates
12.22. United Kingdom
13. Competitive Landscape
13.1. Market Share Analysis, 2023
13.2. FPNV Positioning Matrix, 2023
13.3. Competitive Scenario Analysis
13.3.1. Burjeel Holdings To Launch Rare Disease Research & Development Project ‘Nader’ In Partnership With US-Based Bridgebio Pharma
13.3.2. NIH Launches USD 140 Million Effort To Investigate Genetic Variation In Normal Human Cells And Tissues
13.3.3. CENTOGENE Launches NEW CentoGenome, A Whole Genome Sequencing Solution for Diagnosis of Rare and Neurodegenerative Diseases
14. Competitive Portfolio
14.1. Key Company Profiles
14.2. Key Product Portfolio

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